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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

PD-1 and PD-L1 regulate cellular immunity in canine visceral leishmaniasis

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Autor(es):
Oliveira Silva, Kathlenn Liezbeth [1] ; Chiku, Vanessa Marin [1] ; Venturin, Gabriela Luvizotto [1] ; Correa Leal, Aline Aparecida [1] ; de Almeida, Breno Fernando [1] ; Eugenio, Flavia de Rezende [1] ; Patto dos Santos, Paulo Sergio [1] ; Machado, Gisele Fabrino [1] ; Felix de Lima, Valeria Marcal [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista Julio de Mesquita Filho UN, Sch Vet Med Aracatuba FMVA, Dept Med Surg & Anim Reprod, Cellular Immunol Lab, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES; v. 62, p. 76-87, FEB 2019.
Citações Web of Science: 0
Resumo

PD-1 is a negative costimulator of chronic infectious diseases In this study, we investigated the expression of PD-1 and its ligands in the spleen of dogs with visceral leishmaniasis and lymphoproliferative response to soluble antigen, in lymph node cells in the presence or absence of antibodies blocking PD-1 and its ligands. Our results showed expression of PD-1 and its ligands is higher after L. infantum infection and in the spleen of infected dogs, PD-1 blockage was able to restore the antigen-dependent lymphoproliferative response and regulated production of the cytokines IL-4 and IL-10 and NO production. We concluded that L. infantum infection modulates PD-1 and its ligands expression in canine VL and that blockage of PD-1 restores the immune response. Thus, blockage of PD-1 is a target for therapeutic drug development. (AU)

Processo FAPESP: 13/06684-9 - PD1, apoptose e atividade arginase na leishmaniose visceral canina
Beneficiário:Valéria Marçal Felix de Lima
Modalidade de apoio: Auxílio à Pesquisa - Regular