| Full text | |
| Author(s): |
Oliveira Silva, Kathlenn Liezbeth
[1]
;
Chiku, Vanessa Marin
[1]
;
Venturin, Gabriela Luvizotto
[1]
;
Correa Leal, Aline Aparecida
[1]
;
de Almeida, Breno Fernando
[1]
;
Eugenio, Flavia de Rezende
[1]
;
Patto dos Santos, Paulo Sergio
[1]
;
Machado, Gisele Fabrino
[1]
;
Felix de Lima, Valeria Marcal
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Estadual Paulista Julio de Mesquita Filho UN, Sch Vet Med Aracatuba FMVA, Dept Med Surg & Anim Reprod, Cellular Immunol Lab, Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES; v. 62, p. 76-87, FEB 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
PD-1 is a negative costimulator of chronic infectious diseases In this study, we investigated the expression of PD-1 and its ligands in the spleen of dogs with visceral leishmaniasis and lymphoproliferative response to soluble antigen, in lymph node cells in the presence or absence of antibodies blocking PD-1 and its ligands. Our results showed expression of PD-1 and its ligands is higher after L. infantum infection and in the spleen of infected dogs, PD-1 blockage was able to restore the antigen-dependent lymphoproliferative response and regulated production of the cytokines IL-4 and IL-10 and NO production. We concluded that L. infantum infection modulates PD-1 and its ligands expression in canine VL and that blockage of PD-1 restores the immune response. Thus, blockage of PD-1 is a target for therapeutic drug development. (AU) | |
| FAPESP's process: | 13/06684-9 - PD1, apoptosis and arginase in canine visceral leishmaniasis |
| Grantee: | Valéria Marçal Felix de Lima |
| Support Opportunities: | Regular Research Grants |