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PD1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis

Grant number: 13/19399-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2013
Effective date (End): August 31, 2015
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Valéria Marçal Felix de Lima
Grantee:Vanessa Marim Chiku
Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Visceral Leishmaniasis (VL) in humans is a chronic and often fatal if left untreated and is expansion with an increase also in the state of São Paulo, in regions with urban characteristics as Araçatuba. According to the Secretary of the Epidemiological Surveillance of São Paulo, the disease is expanding with a high mortality rate, being that Araçatuba the largest number of cases the state.The canine VL is a serious public health problem, because infected animals are potent transmitters of the parasite to humans through vector flebotomínio, and canine disease is more prevalent than the human disease, canine cases usually precede human cases. The dog is therefore an important goal in the control measures. The progression of canine infection is accompanied by a failure of cellular immunity with reduced circulating lymphocytes and the production of cytokines that suppress the function of macrophage microbicidal, the suppression of T cells is due to apoptosis, but the mechanisms that lead to failure in the immune response are poorly understood. Recently the involvement of the receptor PD-1 costimulatory negative in adaptive responses in chronic infectious diseases have been reported. This receptor is present in immune cells when bound to its counter-receptor PD-L1 or PD-L2 initiates inhibitory signals that lead to deactivation of T cells or the apoptotic process, PD1 receptor and its ligands act together regulating immune responses. However no study has evaluated whether apoptosis observed in T cells, or IL-4 or IL-10 which suppress cellular response in dogs with Visceral leishmaniasis is related to these molecules. Thus it is intended to check in naturally infected dogs if apoptosis may be due to the expression of the molecule PD1 and its ligands. To that apoptosis will be assessed in T cells and levels of IL-10 and IL-4 evaluated in the presence of blocking antibodies to PD-1 and its ligands. Knowledge of this study may be useful in the design of immunotherapeutic drugs. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHIKU, VANESSA MARIM; OLIVEIRA SILVA, KATHLENN LIEZBETH; MARTINS DE ALMEIDA, BRENO FERNANDO; VENTURIN, GABRIELA LOVIZUTTO; CORREA LEAL, ALINE APARECIDA; DE MARTINI, CLEBER COSTA; EUGENIO, FLAVIA DE REZENDE; PATTO DOS SANTOS, PAULO SERGIO; FELIX DE LIMA, VALERIA MARCAL. PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis. Immunobiology, v. 221, n. 8, p. 879-888, . (13/19399-0, 13/06684-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CHIKU, Vanessa Marim. Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.

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