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Role of Fas and TNF in the apoptosis of CD4 T lymphocyte and CD8 T lymphocyte in dogs with visceral leishmaniasis

Grant number: 11/06214-7
Support type:Regular Research Grants
Duration: October 01, 2011 - September 30, 2013
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Valéria Marçal Felix de Lima
Grantee:Valéria Marçal Felix de Lima
Home Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
Assoc. researchers: Flávia de Rezende Eugênio ; Paulo Sergio Patto dos Santos


The Canine visceral leishmaniasis (CVL) is one of the most important emerging diseases with high prevalence in Latin America, caused largely by the Leishmania (L.) chagasi. The LVC has a major impact on public health, because domestic dogs are the most important reservoirs of the disease, both in urban as in peri-urban areas. So the dog is an important target for the adoption of control measures. Symptomatic infected dogs show a suppression of cell-mediated immunity, apoptosis of T lymphocytes has been associated with suppression of cellular response in experimental infection. To investigate whether apoptosis of T lymphocytes is involved in suppression of cellular response in dogs naturally infected apoptosis of CD4 and CD8 peripheral blood and spleen of dogs naturally infected with L. (L.) chagasi with clinical manifestations will be quantified and compared to healthy dogs. The mechanisms that induce apoptosis are also evaluated. Fifteen symptomatic adult dogs infected with L. (L.) chagasi and six healthy dogs from non endemic area (controls) will be included in the study. Samples from spleen and peripheral blood will be used for quantification of apoptosis and investigate the possible mechanisms that induce the process. In dogs naturally infected immune suppression observed may be related to the mechanism of apoptosis in T-lymphocyte stimulation due to the constant feature of chronic infection can trigger apoptosis and cooperate in the failure of cellular immunity, the definition of what population is undergoing apoptosis and characterization of the inducing mechanisms may be important for understanding the factors responsible for suppression of cellular immunity. The understanding of this mechanism in infected dogs may allow future therapeutic interventions to reduce the depletion of lymphocytes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEROSSO, JULIANA; OLIVEIRA SILVA, KATHLENN LIEZBETH; DE SOUZA FERREIRA, STEFANI IRIS; AVANCO, SAULO VINICIUS; PATTO DOS SANTOS, PAULO SERGIO; EUGENIO, FLAVIA DE REZENDE; MARTINS DE ALMEIDA, BRENO FERNANDO; FELIX DE LIMA, VALERIA MARCAL. Alteration of sFAS and sFAS ligand expression during canine visceral leishmaniosis. Veterinary Parasitology, v. 205, n. 3-4, p. 417-423, OCT 15 2014. Web of Science Citations: 12.
OLIVEIRA SILVA, KATHLENN LIEZBETH; MELO, LARISSA MARTINS; PEROSSO, JULIANA; OLIVEIRA, BRUNA BRITO; PATTO DOS SANTOS, PAULO SERGIO; EUGENIO, FLAVIA DE REZENDE; FELIX DE LIMA, VALERIA MARCAL. CD95 (FAS) and CD178 (FASL) induce the apoptosis of CD4+and CD8+cells isolated from the peripheral blood and spleen of dogs naturally infected with Leishmania spp. Veterinary Parasitology, v. 197, n. 3-4, p. 470-476, NOV 8 2013. Web of Science Citations: 5.

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