Insect venom phospholipases A1 and A2: Roles in the envenoming process and allergy

Autor(es)

Perez-Riverol, Amilcar ^[1] ; Lasa, Alexis Musacchio ^[2] ; Aparecido dos Santos-Pinto, Jose Roberto ^[1] ; Palma, Mario Sergio ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Inst Biosci Rio Claro, Dept Biol, Ctr Study Social Insects, BR-13500 Rio Claro, SP - Brazil

^[2] Ctr Genet Engn & Biotechnol, Biomed Res Div, Dept Syst Biol, Ave 31, E-158 & 190, POB 6162, Havana 10600 - Cuba

• Tipo de documento: Artigo de Revisão
• Fonte: Insect Biochemistry and Molecular Biology; v. 105, p. 10-24, FEB 2019.
• Citações Web of Science: 1

Resumo

Insect venom phospholipases have been identified in nearly all clinically relevant social Hymenoptera, including bees, wasps and ants. Among other biological roles, during the envenoming process these enzymes cause the disruption of cellular membranes and induce hypersensitive reactions, including life threatening anaphylaxis. While phospholipase A2 (PLA2) is a predominant component of bee venoms, phospholipase A1(PLA1) is highly abundant in wasps and ants. The pronounced prevalence of IgE-mediated reactivity to these allergens in sensitized patients emphasizes their important role as major elicitors of Hymenoptera venom allergy (HVA). PLA1 and -A2 represent valuable marker allergens for differentiation of genuine sensitizations to bee and/or wasp venoms from cross-reactivity. Moreover, in massive attacks, insect venom phospholipases often cause several pathologies that can lead to fatalities. This review summarizes the available data related to structure, model of enzymatic activity and pathophysiological roles during envenoming process of insect venom phospholipases A1 and -A2. (AU)

• Processo FAPESP: 16/16212-5 - Proteopeptídeos naturais da fauna, flora e microbiota brasileira como potenciais modelos para o desenvolvimento racional de novos fármacos de uso terapêutico: isolamento, elucidação estrutural, síntese química e ensaios de atividade funcional
• Beneficiário: Mario Sergio Palma
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 17/22405-3 - Identificação e síntese de peptídeos correspondentes a epítopos lineares de células-b de alérgenos do veneno de hymenoptera sociais: desenvolvimento de insumos para diagnóstico e imunoterapia de alergia
• Beneficiário: Amilcar Perez Riverol
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado