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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Insect venom phospholipases A1 and A2: Roles in the envenoming process and allergy

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Author(s):
Perez-Riverol, Amilcar [1] ; Lasa, Alexis Musacchio [2] ; Aparecido dos Santos-Pinto, Jose Roberto [1] ; Palma, Mario Sergio [1]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ, UNESP, Inst Biosci Rio Claro, Dept Biol, Ctr Study Social Insects, BR-13500 Rio Claro, SP - Brazil
[2] Ctr Genet Engn & Biotechnol, Biomed Res Div, Dept Syst Biol, Ave 31, E-158 & 190, POB 6162, Havana 10600 - Cuba
Total Affiliations: 2
Document type: Review article
Source: Insect Biochemistry and Molecular Biology; v. 105, p. 10-24, FEB 2019.
Web of Science Citations: 1
Abstract

Insect venom phospholipases have been identified in nearly all clinically relevant social Hymenoptera, including bees, wasps and ants. Among other biological roles, during the envenoming process these enzymes cause the disruption of cellular membranes and induce hypersensitive reactions, including life threatening anaphylaxis. While phospholipase A2 (PLA2) is a predominant component of bee venoms, phospholipase A1(PLA1) is highly abundant in wasps and ants. The pronounced prevalence of IgE-mediated reactivity to these allergens in sensitized patients emphasizes their important role as major elicitors of Hymenoptera venom allergy (HVA). PLA1 and -A2 represent valuable marker allergens for differentiation of genuine sensitizations to bee and/or wasp venoms from cross-reactivity. Moreover, in massive attacks, insect venom phospholipases often cause several pathologies that can lead to fatalities. This review summarizes the available data related to structure, model of enzymatic activity and pathophysiological roles during envenoming process of insect venom phospholipases A1 and -A2. (AU)

FAPESP's process: 16/16212-5 - Natural proteopeptides from the Brazilian fauna, flora and microbiota as potential models for the rational development of new drugs of therapeutic use: isolation, structure elucidation, chemical synthesis and functional activity assays
Grantee:Mario Sergio Palma
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 17/22405-3 - IDENTIFICATION AND SYNTHESIS OF PEPTIDES CORRESPONDING TO B-CELL LINEAR EPITOPES IN ALLERGENS FROM VENOM OF SOCIAL HYMENOPTERA: DEVELOPMENT OF SUPPLIES FOR DIAGNOSIS AND IMMUNOTHERAPY OF ALLERGY
Grantee:Amilcar Perez Riverol
Support Opportunities: Scholarships in Brazil - Post-Doctoral