Caracterização de genes de resistência de Klebsiella pneumoniae produtoras de KPC ...
- Auxílios pontuais (curta duração)
| Texto completo | |
| Autor(es): |
Espinal, P.
[1, 2]
;
Nucleo, E.
[3]
;
Caltagirone, M.
[3]
;
Marchetti, V. Mattioni
[3]
;
Fernandes, M. R.
[4, 1]
;
Biscaro, V
[5]
;
Rigoli, R.
[5]
;
Carattoli, A.
[1]
;
Migliavacca, R.
[3]
;
Villa, L.
[1]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Ist Super Sanita, Dept Infect Dis, Viale Regina Margherita 299, I-00161 Rome - Italy
[2] Inst Invest Biomed St Pau IIB St Pau, Servei Microbiol Hosp Santa Creu & St Pau, Barcelona - Spain
[3] Univ Pavia, Unit Microbiol & Clin Microbiol, Clin Surg Diagnost & Paediat Sci Dept, Pavia - Italy
[4] Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo - Brazil
[5] Treviso Hosp, Microbiol Dept, Treviso - Italy
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Clinical Microbiology and Infection; v. 25, n. 3 MAR 2019. |
| Citações Web of Science: | 3 |
| Resumo | |
Objectives: Genomic characterization of the internationally spread sequence type (ST) 16 carbapenemresistant Klebsiella pneumoniae. Methods: The complete genomes of three carbapenem producing ST16 K. pneumoniae from Italian patients were analysed by single-nucleotide polymorphism-based phylogeny, core genome multilocus sequence typing, resistance, plasmid, and virulence content and compared with ten genomes of ST16 strains isolated in other countries. Plasmids carrying blaNDM-1 or blaOXA-232 carbapenemase genes were assembled and sequences were analysed. Results: The internationally spread ST16 K. pneumoniae clone showed variability in terms of distribution of NDM-1 and OXA-232 type carbapenemases. In some ST16 strains, up to six plasmids can be simultaneously present in the same cell, including ColE-like plasmids carrying blaOXA-232 and IncF plasmids carrying blaNDM-1. The differences observed in plasmid, resistance, and virulence content and core genome suggested that there is not a unique, highly conserved ST16 clone, but instead different variants of this lineage circulate worldwide. Conclusions: The ST16 K. pneumoniae clone has spread worldwide and may become a high-risk clone. (c) 2018 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. (AU) | |
| Processo FAPESP: | 17/16754-5 - Caracterização de plasmídeos associado com a disseminação de resistência a colistina MCR-1 gene em Enterobacteriaceae clinicamente significantes de países da América do Sul e da Europa |
| Beneficiário: | Miriam Rodriguez Fernandes |
| Linha de fomento: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |