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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Genomics of Klebsiella pneumoniae ST16 producing NDM-1, CTX-M-15, and OXA-232

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Autor(es):
Espinal, P. [1, 2] ; Nucleo, E. [3] ; Caltagirone, M. [3] ; Marchetti, V. Mattioni [3] ; Fernandes, M. R. [4, 1] ; Biscaro, V [5] ; Rigoli, R. [5] ; Carattoli, A. [1] ; Migliavacca, R. [3] ; Villa, L. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Ist Super Sanita, Dept Infect Dis, Viale Regina Margherita 299, I-00161 Rome - Italy
[2] Inst Invest Biomed St Pau IIB St Pau, Servei Microbiol Hosp Santa Creu & St Pau, Barcelona - Spain
[3] Univ Pavia, Unit Microbiol & Clin Microbiol, Clin Surg Diagnost & Paediat Sci Dept, Pavia - Italy
[4] Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo - Brazil
[5] Treviso Hosp, Microbiol Dept, Treviso - Italy
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Clinical Microbiology and Infection; v. 25, n. 3 MAR 2019.
Citações Web of Science: 3
Resumo

Objectives: Genomic characterization of the internationally spread sequence type (ST) 16 carbapenemresistant Klebsiella pneumoniae. Methods: The complete genomes of three carbapenem producing ST16 K. pneumoniae from Italian patients were analysed by single-nucleotide polymorphism-based phylogeny, core genome multilocus sequence typing, resistance, plasmid, and virulence content and compared with ten genomes of ST16 strains isolated in other countries. Plasmids carrying blaNDM-1 or blaOXA-232 carbapenemase genes were assembled and sequences were analysed. Results: The internationally spread ST16 K. pneumoniae clone showed variability in terms of distribution of NDM-1 and OXA-232 type carbapenemases. In some ST16 strains, up to six plasmids can be simultaneously present in the same cell, including ColE-like plasmids carrying blaOXA-232 and IncF plasmids carrying blaNDM-1. The differences observed in plasmid, resistance, and virulence content and core genome suggested that there is not a unique, highly conserved ST16 clone, but instead different variants of this lineage circulate worldwide. Conclusions: The ST16 K. pneumoniae clone has spread worldwide and may become a high-risk clone. (c) 2018 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. (AU)

Processo FAPESP: 17/16754-5 - Caracterização de plasmídeos associado com a disseminação de resistência a colistina MCR-1 gene em Enterobacteriaceae clinicamente significantes de países da América do Sul e da Europa
Beneficiário:Miriam Rodriguez Fernandes
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado