A new dye based on anthocyanins from the acai fruit (Euterpe oleracea) for chromovitrectomy in humans: clinical trial results

Autor(es)

Caiado, Rafael R. ^[1] ; Peris, Cristiane ^[1] ; Rodrigues, Eduardo B. ^[1] ; Farah, Michel Eid ^[1] ; Maia, Andre ^[1] ; Magalhaes, Octaviano ^[1] ; Novais, Eduardo ^[1] ; Lima-Filho, Acacio Souza ^{[1, 2]} ; Maia, Mauricio ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Ophthalmol, Vis Inst, 781 Pedro Toledo St, 2nd Floor, BR-04039032 Sao Paulo - Brazil

^[2] Ophthalmos Pharmaceut Ind, Sao Paulo - Brazil

^[3] Assis Presidente Prudente, Brazilian Inst Fight Blindness, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GRAEFES' ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY; v. 257, n. 3, p. 517-528, MAR 2019.
• Citações Web of Science: 1

Resumo

PurposeTo test the applicability of the acai dye at a 25% concentration for identifying the posterior hyaloids and internal limiting membranes (ILMs) during pars plana vitrectomy (PPV) in human eyes with macular holes (MHs).MethodsThis study included 25 patients with chronic idiopathic MHs. The exclusion criteria included glaucoma, previous significant ocular conditions, and previous ocular surgeries except uncomplicated cataract. Ten surgeons performed 23-gauge four-port PPV, phacoemulsification, posterior hyaloid detachment, ILM peeling guided by dye staining, and perfluoropropane injection. The patients remained prone for 5days postoperatively. The patients were evaluated postoperatively after 1, 30, and 180days. The surgeons completed a questionnaire regarding the dye's staining abilities.ResultsThe posterior hyaloids and ILMs stained purple in all eyes. The final best-corrected visual acuity improved significantly (p<0.001) from preoperatively (1.370.29) to 180days postoperatively (1.05 +/- 0.43). The MHs closed in 76% of eyes.Conclusion The acai dye at a 25% concentration identified posterior hyaloids and ILMs during PPVs in humans. Dye toxicity was unlikely. (AU)

• Processo FAPESP: 14/07686-8 - Aplicabilidade do corante composto pelas antocianinas e proantocianidinas do fruto do açaí (Euterpe orelacea) em cromovitrectomia em humanos
• Beneficiário: Eduardo Büchele Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Regular