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Acute kidney injury induced by thrombotic microangiopathy in two cases of Bothrops envenomation

Texto completo
Malaque, C. M. S. [1, 2] ; Duayer, I. F. [1] ; Santoro, M. L. [3]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Emilio Ribas Inst Infectol, Sao Paulo - Brazil
[2] Vital Brazil Hosp, Butantan Inst, Av Dr Vital Brasil 1500, BR-05503900 Sao Paulo - Brazil
[3] Butantan Inst, Lab Pathophysiol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: CLINICAL TOXICOLOGY; v. 57, n. 3, p. 213-216, MAR 4 2019.
Citações Web of Science: 0

Context: Bothrops snakes are the most frequent agents of snakebites in South and Central America. Acute kidney injury (AKI) is one of its complications and has multifactorial origin. Thrombotic microangiopathy (TMA)-induced AKI in snakebites is uncommon and is not described in Bothrops envenomation. Case details: We report two cases of patients bitten by young Bothrops jararaca who developed AKI induced by TMA. Both patients evolved with mild envenomation and received the specific antivenom within 4 h after the snakebite. None of them had hypotension or shock, bleeding or secondary infection. Patient 1 (P1) was diabetic and using oral hypoglycemic drugs, and patient 2 (P2) was hypertensive without regular use of medication. On admission, both patients had levels of fibrinogen lower than 35 mg/dL, D-dimer higher than 10,000 ng/mL. They evolved with AKI, thrombocytopenia, normal coagulation assays, anemia, lactate dehydrogenase (LDH) elevation, low haptoglobin levels, negative direct antiglobulin test, and presence of schizocytes in peripheral blood. Only P1 required renal replacement therapy, and plasmapheresis was not required. Both patients were discharged and did not require outpatient dialysis, and subsequently had normal creatinine levels. Discussion: TMA may occur in Bothrops jararaca envenomation, even in mild cases that received early specific antivenom. (AU)

Processo FAPESP: 13/25177-0 - Envolvimento do fator de Von Willebrand nos distúrbios hemostáticos do envenenamento pela serpente Bothrops jararaca: estudo experimental
Beneficiário:Marcelo Larami Santoro
Linha de fomento: Auxílio à Pesquisa - Regular