Interleukin-10 responses from acute exercise in healthy subjects: A systematic review

Autor(es)

Cabral-Santos, Carolina ^[1] ; de Lima Junior, Edson Alves ^[2] ; da Cruz Fernandes, Isabela Maia ^[1] ; Pinto, Rafael Zambelli ^[3] ; Rosa-Neto, Jose Cesar ^[2] ; Bishop, Nicolette Charllote ^{[4, 5]} ; Lira, Fabio Santos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Exercise & Immunometab Res Grp, Postgrad Program Movement Sci, Dept Phys Educ, Presidente Prudente, SP - Brazil

^[2] Univ Sao Paulo, Dept Cell & Dev Biol, Immunometab Res Grp, Butanta, SP - Brazil

^[3] Univ Fed Minas Gerais, Dept Phys Therapy, Belo Horizonte, MG - Brazil

^[4] Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough, Leics - England

^[5] Loughborough Univ, Natl Ctr Sport & Exercise Med, Loughborough, Leics - England

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Cellular Physiology; v. 234, n. 7, p. 9956-9965, JUL 2019.
• Citações Web of Science: 6

Resumo

PurposeInterleukin 10 (IL-10) is a cytokine that plays a critical role with potent anti-inflammatory properties when produced during exercise, limiting host immune response to pathogens and preventing tissue damage. The purpose of this systematic review was to assess the response of IL-10 after acute exercise session in healthy adults. MethodsDatabases of Ovid Medline (1978-2016), CINAHL (1998-2016), EMBASE (2003-2016), SportDiscus (1990-2016), and Web of Science library (1990-2016) were carefully screened. Clinical trials comparing exercise types in healthy individuals were included for pooled analysis. The trials of exercise were methodologically appraised by PEDro Scale. ResultsTwelve randomized controlled and crossover trials containing 176 individuals were identified for inclusion. The Kruskal-Wallis test showed no significant differences between type of exercise and the corresponding values in IL-10 {[}X2(4)=2.878; p=0.449]. The duration of exercise was significantly correlated with increase in IL-10 changes (Pearson's r=1.00, 95%CI: 0.015-0.042, p<0.0001) indicating that 48% of the variation in IL-10 levels can be explained by the duration of the exercise performed. In addition, despite a linear increase, we did not find a significant correlation with the intensity of exercise and IL-10 changes (Pearson's r=0.218, 95%CI: -0.554-0.042, p<0.035). ConclusionOverall, the duration of the exercise is the single most important factor determining the magnitude of the exercise-induced increase of plasma IL-10. (AU)

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