Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression

Autor(es)

Oliveira, Isadora S. ^[1] ; Ferreira, Isabela G. ^[1] ; Alexandre-Silva, Gabriel M. ^[2] ; Cerni, Felipe A. ^[3] ; Cremonez, Caroline M. ^[1] ; Arantes, Eliane C. ^[1] ; Zottich, Umberto ^[2] ; Pucca, Manuela B. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, Ribeirao Preto, SP - Brazil

^[2] Univ Fed Roraima, Med Sch, Boa Vista, RR - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 25, APR 15 2019.
• Citações Web of Science: 1

Resumo

Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases. (AU)

• Processo FAPESP: 18/21233-7 - Análises por espectrometria de massas de uma nova fosfodiesterase da peçonha de Crotalus durissus collilineatus
• Beneficiário: Isadora Sousa de Oliveira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 17/14035-1 - Melhoramento de fragmentos de anticorpos humanos (scFVs) específicos para peçonhas animais
• Beneficiário: Felipe Augusto Cerni
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/14158-9 - Melhoramento de fragmentos de anticorpos humanos (scFvs) específicos para peçonhas animais
• Beneficiário: Felipe Augusto Cerni
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 17/03580-9 - Avaliação bioquímica, estrutural e funcional de uma fosfodiesterase da peçonha de Crotalus durissus collilineatus
• Beneficiário: Isadora Sousa de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado