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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression

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Author(s):
Oliveira, Isadora S. [1] ; Ferreira, Isabela G. [1] ; Alexandre-Silva, Gabriel M. [2] ; Cerni, Felipe A. [3] ; Cremonez, Caroline M. [1] ; Arantes, Eliane C. [1] ; Zottich, Umberto [2] ; Pucca, Manuela B. [2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, Ribeirao Preto, SP - Brazil
[2] Univ Fed Roraima, Med Sch, Boa Vista, RR - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 25, APR 15 2019.
Web of Science Citations: 1
Abstract

Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases. (AU)

FAPESP's process: 18/21233-7 - Mass spectrometry analysis of a new phosphodiesterase from Crotalus durissus collilineatus venom
Grantee:Isadora Sousa de Oliveira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 17/14035-1 - Improving of human fragment antibodies (scFvs) specific for animals' venoms
Grantee:Felipe Augusto Cerni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/03580-9 - Biochemical, structural and functional evaluation of a phosphodiesterase from Crotalus durissus collilineatus venom
Grantee:Isadora Sousa de Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/14158-9 - Improving of human fragment antibodies (scFvs) specific for animals' venoms
Grantee:Felipe Augusto Cerni
Support type: Scholarships abroad - Research Internship - Post-doctor