| Texto completo | |
| Autor(es): |
Soares, Paulo Victoria
[1]
;
Kannen, Vinicius
[2]
;
Jordao Junior, Alceu Afonso
[3]
;
Garcia, Sergio Britto
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Pathol, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Dept Toxicol Bromatol & Clin Anal, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Dept Internal Med, Ribeirao Preto - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL; v. 71, n. 4, p. 615-623, MAY 19 2019. |
| Citações Web of Science: | 2 |
| Resumo | |
Colorectal cancer (CRC) is the third most frequent malignancy worldwide. Coffee is the second most consumed drink in the globe and suggested to decrease the CRC risk. Here, we explored whether coffee, decaffeinated coffee, or caffeine impact on the development of colorectal carcinogenesis induced by the direct carcinogen N-methyl-N-nitro-N-nitrosoguanidine (MNNG) in rats. To this end, sixty-four young male Wistar rats were divided into eight groups of eight animals each. We analyzed the frequency of dysplastic crypts and expression of metallothionein as a biomarker of the cancer risk, as well the expression of phosphorylated H2A histone family/member X (gamma H2AX) for DNA damage and cyclooxygenase-2 (COX-2) for inflammatory response. We also studied the oxidative stress profile in hepatic and colonic frozen samples (malondialdehyde {[}MDA], glutathione {[}GSH], and alpha-tocopherol). We found that coffee but neither decaffeinated coffee nor caffeine decreased the development of dysplastic crypts in MNNG-exposed rats. All treatments reduced DNA damage intensity in colonocytes. Only decaffeinated coffee increased the numbers of metallothionein positive crypts in comparison with coffee-treated rats. Coffee and caffeine inhibited COX-2 expression in the colon. Both decaffeinated coffee and caffeine decreased hepatic alpha-tocopherol levels. We suggest that coffee may have other compounds that elicit greater chemoprotective effects than caffeine reducing the CRC risk. (AU) | |
| Processo FAPESP: | 14/06428-5 - Como a sinalização serotoninérgica epitelial difere dos efeitos de sua síntese neural durante a inflamação associada ou não ao câncer de cólon |
| Beneficiário: | Vinicius Kannen Cardoso |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 15/01723-1 - Como a sinalização serotoninérgica epitelial difere dos efeitos de sua síntese neural durante a carcinogênese de cólon |
| Beneficiário: | Vinicius Kannen Cardoso |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |