Synthesis, characterization and biological evaluation of new manganese metal carbonyl compounds that contain sulfur and selenium ligands as a promising new class of CORMs

Autor(es):Mostrar menos -

Amorim, Andre L. ^[1] ; Peterle, Marcos M. ^[1] ; Guerreiro, Ana ^[2] ; Coimbra, Daniel F. ^[1] ; Heying, Renata S. ^[1] ; Caramori, Giovani F. ^[1] ; Braga, Antonio L. ^[1] ; Bortoluzzi, Adailton J. ^[1] ; Neves, Ademir ^[1] ; Bernardes, Goncalo J. L. ^{[3, 2]} ; Peralta, Rosely A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC - Brazil

^[2] Univ Lisbon, Fac Med, Inst Med Mol, Ave Prof Egas Moniz, P-1649028 Lisbon - Portugal

^[3] Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW - England

• Tipo de documento: Artigo Científico
• Fonte: DALTON TRANSACTIONS; v. 48, n. 17, p. 5574-5584, MAY 7 2019.
• Citações Web of Science: 6

Resumo

Three new manganese carbonyl compounds with heavy atom donors were synthesized and their potential use as photoCORMS was evaluated. Interestingly, all compounds had an elusive binding mode, in which the ligands adopted a kappa(2)-X coordination (where X = S or Se), confirmed both by X-ray crystallography and IR spectroscopy. The stability of the title compounds in the dark was determined by monitoring the changes in the UV spectra of the compounds in both dichloromethane and acetonitrile. These studies show that in coordinating solvents there is an exchange of the bromide bonded to the metal centre by a solvent molecule, which is evidenced by the changes in the UV and IR spectra and by DFT analysis. EDA and natural bond order analyses were conducted to evaluate the influence of the heavy atom donors in the first coordination sphere of the compounds. Photoexcitation at 380 nm demonstrated that all compounds showed release of all three COs, as seen in the photoproducts detected by IR spectroscopy. Furthermore, CO release was observed when the photoCORMs were incubated with living cells, and we observed a CO-dependent inhibition of cell viability. (AU)

• Processo FAPESP: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia