Galleria mellonella as an experimental model to study human oral pathogens

Autor(es)

Rossoni, Rodnei Dennis ^[1] ; Ribeiro, Felipe de Camargo ^[1] ; Santana dos Santos, Hanna Flavia ^[1] ; dos Santos, Jessica Diane ^[1] ; Oliveira, Nicassia de Sousa ^[1] ; dos Santos Dutra, Marignes Theotonio ^[1] ; Biazzi de Lapena, Simone Aparecida ^[1] ; Junqueira, Juliana Campos ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 101, p. 13-22, MAY 2019.
• Citações Web of Science: 3

Resumo

The oral cavity is home to a microbial community of more than 800 species. This important microbiome is formed by commensal and opportunistic bacteria, fungi and viruses. Several distinct habitats within the mouth support heterogeneous microbial communities that constitute an important link between oral and general health. The use of animal models for in vivo studies in microbial pathogenicity is well established in the scientific community. Galleria mellonella as a model host has increased in use significantly in the last few years. This invertebrate model provides studies on a large scale, serving as screens for studies on vertebrate animals, such as mice and rats. In this review, different studies of microbial genera of dental importance (Enterococcus, Candida, Lactobacillus, Porphyromonas and Streptococcus) are discussed, highlighting the use of G. mellonella as a suitable model for studying pathogenesis, efficacy of antimicrobial compounds, and immune responses. (AU)

• Processo FAPESP: 17/19219-3 - Identificação de substâncias bioativas produzidas por Lactobacillus paracasei 28.4 para o controle da candidose bucal
• Beneficiário: Rodnei Dennis Rossoni
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/25544-1 - Desenvolvimento de formulações probióticas para a prevenção da candidose bucal: Estudo in vitro e in vivo
• Beneficiário: Felipe de Camargo Ribeiro
• Linha de fomento: Bolsas no Brasil - Doutorado