B-1 cell response in immunity against parasites

Autor(es)

Novaes e Brito, Ronni Romulo ^[1] ; Toledo, Mayte dos Santos ^[2] ; Labussiere, Gabriela Martins ^[2] ; Dupin, Talita Vieira ^[2] ; de Campos Reis, Natasha Ferraz ^[2] ; Perez, Elizabeth Cristina ^[3] ; Xander, Patricia ^{[2, 4]}

Afiliação do(s) autor(es)

^[1] Ctr Univ Sao Camilo, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo Campus Diadema, Dept Ciencias Farmaceut, Diadema - Brazil

^[3] Univ Paulista, Patol Ambiental & Expt, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo Campus Diadema, Dept Ciencias Farmaceut, Lab Imunol Celular & Bioquim Fungos & Protozoario, Unidade Jose Alencar, Rua Sao Nicolau 210, 4 Andar, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Parasitology Research; v. 118, n. 5, p. 1343-1352, MAY 2019.
• Citações Web of Science: 0

Resumo

The peritoneal cavity has a microenvironment capable of promoting proliferation, differentiation, and activation of the resident cells and recruitment of blood cells through the capillary network involved in the peritoneum. Among the cells found in the peritoneal cavity, B-1 cells are a particular cell type that contains features that are not very well defined. These cells differ from conventional B lymphocytes (B-2) by phenotypic, functional, and molecular characteristics. B-1 cells can produce natural antibodies, migrate to the inflammatory focus, and have the ability to phagocytose pathogens. However, the role of B-1 cells in immunity against parasites is still not completely understood. Several experimental models have demonstrated that B-1 cells can affect the susceptibility or resistance to parasite infections depending on the model and species. Here, we review the literature to provide information on the peculiarities of B-1 lymphocytes as well as their interaction with parasites. (AU)

• Processo FAPESP: 16/17245-4 - Avaliação dos efeitos das vesículas extracelulares liberadas por promastigotas de Leishmania amazonensis na resposta de macrófagos e na progressão da doença
• Beneficiário: Patricia Xander Batista
• Modalidade de apoio: Auxílio à Pesquisa - Regular