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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Histopathological features of juvenile-onset laryngeal papillomatosis related to severity

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Autor(es):
Ribeiro El Achkar, Vivian Narana [1] ; Duarte, Andressa [2] ; Carlos, Roman [3] ; Leon, Jorge Esquiche [4] ; Ribeiro-Silva, Alfredo [5] ; Nagata Pignatari, Shirley Shizue [6] ; Kaminagakura, Estela [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ Unesp, Inst Sci & Technol, Dept Biosci & Oral Diag, Engn Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[2] Univ Sao Paulo, Dept Pathol, Ribeirao Preto Sch Med, Ribeirao Preto - Brazil
[3] Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala
[4] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Stomatol Collect Hlth & Legal Dent, Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Dept Pathol & Legal Med, Ribeirao Preto Sch Med, Ribeirao Preto - Brazil
[6] Sao Paulo Fed Univ, Dept Otorhinolaryngol & Head & Neck Surg, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 41, n. 5, p. 1412-1417, MAY 2019.
Citações Web of Science: 1
Resumo

Background Laryngeal papillomatosis (LP) is a disease that presents in both juvenile (JLP) and adult patients (ALP). This study correlated papillomatosis characteristics with the Derkay score. Methods Retrospective data and biopsies of 36 patients with JLP and 56 with ALP were collected and separated into groups according to their scores. Results The mean of the Derkay score, in the JLP group was 10.97 and in Group ALP was 8.26. The JLP group presented a more aggressive result than in the adult group (P = .02). In the JLP group, the respiratory difficulty (P = .01) and tracheostomy were correlated to a higher Derkay score (P < .05). Microscopically, the JLP samples presented a higher incidence of atypical mitosis and mitosis above the basal cells layer of the epithelium (P < .05) and these characteristics were correlated with a higher Derkay index (P = .03). Conclusion Findings suggest that ALP and JLP can present different clinical courses and histopathological features. There was a higher degree of LP severity in JLP. (AU)

Processo FAPESP: 16/24019-0 - Investigação da presença de epstein-barr vírus e sua possível contribuição na agressividade e malignização da papilomatose laríngea
Beneficiário:Estela Kaminagakura Tango
Modalidade de apoio: Auxílio à Pesquisa - Regular