| Full text | |
| Author(s): |
Ribeiro El Achkar, Vivian Narana
[1]
;
Duarte, Andressa
[2]
;
Carlos, Roman
[3]
;
Leon, Jorge Esquiche
[4]
;
Ribeiro-Silva, Alfredo
[5]
;
Nagata Pignatari, Shirley Shizue
[6]
;
Kaminagakura, Estela
[1]
Total Authors: 7
|
| Affiliation: | [1] Sao Paulo State Univ Unesp, Inst Sci & Technol, Dept Biosci & Oral Diag, Engn Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[2] Univ Sao Paulo, Dept Pathol, Ribeirao Preto Sch Med, Ribeirao Preto - Brazil
[3] Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala
[4] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Stomatol Collect Hlth & Legal Dent, Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Dept Pathol & Legal Med, Ribeirao Preto Sch Med, Ribeirao Preto - Brazil
[6] Sao Paulo Fed Univ, Dept Otorhinolaryngol & Head & Neck Surg, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 41, n. 5, p. 1412-1417, MAY 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Background Laryngeal papillomatosis (LP) is a disease that presents in both juvenile (JLP) and adult patients (ALP). This study correlated papillomatosis characteristics with the Derkay score. Methods Retrospective data and biopsies of 36 patients with JLP and 56 with ALP were collected and separated into groups according to their scores. Results The mean of the Derkay score, in the JLP group was 10.97 and in Group ALP was 8.26. The JLP group presented a more aggressive result than in the adult group (P = .02). In the JLP group, the respiratory difficulty (P = .01) and tracheostomy were correlated to a higher Derkay score (P < .05). Microscopically, the JLP samples presented a higher incidence of atypical mitosis and mitosis above the basal cells layer of the epithelium (P < .05) and these characteristics were correlated with a higher Derkay index (P = .03). Conclusion Findings suggest that ALP and JLP can present different clinical courses and histopathological features. There was a higher degree of LP severity in JLP. (AU) | |
| FAPESP's process: | 16/24019-0 - INVESTIGATION OF THE PRESENCE OF EPSTEIN-BARR VIRUS AND ITS POSSIBLE CONTRIBUTION TO LARYNGEAL PAPILLOMATOSIS AGGRESSIVENESS AND MALIGNIZATION |
| Grantee: | Estela Kaminagakura Tango |
| Support Opportunities: | Regular Research Grants |