Genomic characterization and comparative analysis of Leptospira kirschneri serogroup Grippotyphosa UC5/2011, a strain isolated after mare abortion: Implications for genital animal leptospirosis

Autor(es)

Jaeger, Lauren H. ^{[1, 2]} ; Moreno, Luisa Z. ^[3] ; Kremer, Frederico S. ^[4] ; Dellagostin, Odir A. ^[4] ; Moreno, Andrea M. ^[3] ; Lilenbaum, Walter ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Fluminense, Dept Microbiol & Parasitol, Lab Bacteriol Vet, Rua Prof Hernani Melo 101, BR-24210130 Niteroi, RJ - Brazil

^[2] Univ Fed Juiz De Fora, Fac Farm, Rua Jose Lourenco Kelmer S-N, BR-36036900 Juiz De Fora - Brazil

^[3] Univ Sao Paulo, Fac Med Vet & Zootecnia, Lab Epidemiol Mol & Resistencia Antimicrobianos, Ave Prof Orlando Marques de Paiva 87, BR-05508010 Sao Paulo - Brazil

^[4] Univ Fed Pelotas, Nucleo Biotecnol, Ctr Desenvolvimento Tecnol, Rua Gomes Carneiro 1, BR-96010610 Pelotas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES; v. 64, p. 7-9, JUN 2019.
• Citações Web of Science: 0

Resumo

The genome of a Brazilian strain of Leptospira kirschneri serogroup Grippotyphosa isolated from a mare post-abortion was sequenced and analyzed. High symmetrical identity and few structural differences were found when compared with a European strain of the same serogroup, L. kirschneri serovar Valbuzzi strain 200702274. Genes associated with virulence and antimicrobial resistance were found. Knowledge of the virulence evolution of Leptospira remains limited, especially in diseases of the reproductive sphere. We highlight the importance of virulence studies in the sphere of genital leptospirosis. (AU)

• Processo FAPESP: 13/17136-2 - Caracterização de estirpes de Leptospira isoladas no Brasil através de tipificação por eletroforese em campo pulsado (PFGE) e análise comparativa de genomas.
• Beneficiário: Luisa Zanolli Moreno
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/18290-0 - Caracterização de estirpes de Leptospira isoladas no Brasil através da tipagem por sequenciamento de multilocus (MLST)
• Beneficiário: Andrea Micke Moreno
• Modalidade de apoio: Auxílio à Pesquisa - Regular