Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients

Autor(es):Mostrar menos -

Polonis, Katarzyna ^{[1, 2]} ; Sompalli, Sreeja ^[1] ; Becari, Christiane ^{[1, 3]} ; Xie, Jiang ^[1] ; Covassin, Naima ^[1] ; Schulte, Phillip J. ^[4] ; Druliner, Brooke R. ^[5] ; Johnson, Ruth A. ^[5] ; Narkiewicz, Krzysztof ^[2] ; Boardman, Lisa A. ^[5] ; Singh, Prachi ^[1] ; Somers, Virend K. ^[1]

Afiliação do(s) autor(es)

^[1] Mayo Clin, Dept Cardiovasc Med, Rochester, MN 55905 - USA

^[2] Med Univ Gdansk, Fac Med, Dept Hypertens & Diabetol, PL-80210 Gdansk - Poland

^[3] Ribeirao Preto Med Sch, Dept Surg & Anat, BR-14049900 Ribeirao Preto, SP - Brazil

^[4] Mayo Clin, Div Biomed Stat & Informat, Rochester, MN 55905 - USA

^[5] Mayo Clin, Div Gastroenterol & Hepatol, Dept Internal Med, Rochester, MN 55905 - USA

• Tipo de documento: Artigo Científico
• Fonte: CELLS; v. 8, n. 5 MAY 2019.
• Citações Web of Science: 0

Resumo

Telomere length (TL) is associated with cardiovascular disease (CVD) and cancer. Obstructive sleep apnea (OSA) is also linked to higher risk of CVD and cancer, and to TL. We investigated the association between TL and risk of major adverse cardiac events (MACE) and cancer in OSA patients. We studied 210 individuals undergoing sleep-related studies between 2000 and 2007. Baseline characteristics and follow-up data (available in 164 subjects) were obtained from clinic records. Incidence rates were calculated for the entire group and by OSA status. Hazard ratios were calculated to estimate effects of OSA and TL on risk of MACE and cancer. In total, 32 individuals (20%) developed MACE and/or cancer during 12.7-year follow-up. The OSA group had a higher likelihood of cancer (16.0 vs. 4.9 events per 1000 person-years, P = 0.044) but no clear evidence of an elevated incidence of MACE (10.8 vs. 4.8 events per 1000 person-years, P = 0.293) compared to the non-OSA group. There was no association between TL and MACE- (HR = 1.01, 95% CI 0.78-1.28), or cancer-risk (HR = 1.18, 95% CI 0.96-1.43). Our study warrants further investigation of any modulating effect of OSA on TL and the risk of MACE and cancer. (AU)

• Processo FAPESP: 18/23718-8 - Contribuição do sistema renina angiotensina na fisiopatologia do aneurisma de aorta abdominal
• Beneficiário: Christiane Becari
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores