Transcranial Optical Monitoring of Cerebral Hemodynamics in Acute Stroke Patients during Mechanical Thrombectomy

Autor(es):Mostrar menos -

Forti, Rodrigo M. ^{[1, 2, 3]} ; Favilla, Christopher G. ^[4] ; Cochran, Jeffrey M. ^[1] ; Baker, Wesley B. ^[5] ; Detre, John A. ^{[4, 6]} ; Kasner, Scott E. ^[4] ; Mullen, Michael T. ^[4] ; Messe, Steven R. ^[4] ; Kofke, W. Andrew ^[7] ; Balu, Ramani ^[4] ; Kung, David ^{[6, 8]} ; Pukenas, Bryan A. ^{[6, 8]} ; Sedora-Roman, Neda I. ^[6] ; Hurst, Robert W. ^{[6, 8]} ; Choudhri, Omar A. ^[8] ; Mesquita, Rickson C. ^{[2, 3]} ; Yodh, Arjun G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 - USA

^[2] Brazilian Inst Neurosci & Neurotechnol, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Inst Phys, Rua Sergio Buarque de Holanda 777, BR-13083859 Campinas, SP - Brazil

^[4] Univ Penn, Dept Neurol, Philadelphia, PA 19104 - USA

^[5] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 - USA

^[6] Univ Penn, Dept Radiol, Philadelphia, PA 19104 - USA

^[7] Univ Penn, Dept Anesthesiol & Crit Care, Philadelphia, PA 19104 - USA

^[8] Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 - USA

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF STROKE & CEREBROVASCULAR DISEASES; v. 28, n. 6, p. 1483-1494, JUN 2019.
• Citações Web of Science: 0

Resumo

Introduction: Mechanical thrombectomy is revolutionizing treatment of acute stroke due to large vessel occlusion (LVO). Unfortunately, use of the modified Thrombolysis in Cerebral Infarction score (mTICI) to characterize recanalization of the cerebral vasculature does not address microvascular perfusion of the distal parenchyma, nor provide more than a vascular ``snapshot.{''} Thus, little is known about tissue-level hemodynamic consequences of LVO recanalization. Diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS) are promising methods for continuous, noninvasive, contrast-free transcranial monitoring of cerebral microvasculature. Methods: Here, we use a combined DCS/DOS system to monitor frontal lobe hemodynamic changes during endovascular treatment of 2 patients with ischemic stroke due to internal carotid artery (ICA) occlusions. Results and Discussion: The monitoring instrument identified a recanalization-induced increase in ipsilateral cerebral blood flow (CBF) with little or no concurrent change in contralateral CBF and extracerebral blood flow. The results suggest that diffuse optical monitoring is sensitive to intracerebral hemodynamics in patients with ICA occlusion and can measure microvascular responses to mechanical thrombectomy. (AU)

• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 16/13139-5 - Desenvolvimento de sensores ópticos e algoritmos para monitoramento de pacientes em situação neurocrítica
• Beneficiário: Rodrigo Menezes Forti
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado