Is arterial calcification in children and adolescents with end-stage renal disease a rare finding?

Autor(es)

de Menezes, Fernanda L. ^[1] ; Koch-Nogueira, Paulo C. ^[1] ; do Val, Maria L. D. M. ^[1] ; Pestana, Jose O. M. ^[2] ; Jorgetti, Vanda ^[3] ; dos Reis, Marlene A. ^[4] ; dos Reis Monteiro, Maria L. G. ^[4] ; Leite, Heitor P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Pediat, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Hosp Rim, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Internal Med, Sao Paulo - Brazil

^[4] Univ Fed Triangulo Mineiro, Dept Pathol, Uberaba, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEPHROLOGY; v. 24, n. 7, p. 696-702, JUL 2019.
• Citações Web of Science: 0

Resumo

Aim To investigate if calcification and intimal media thickness (IMT) of arteries are present in children and adolescents with end-stage renal disease and to describe the risk factors associated with these alterations. Methods In an observational, cross-sectional prospective study, 68 patients were evaluated at the time of renal transplantation. A fragment of the inferior epigastric artery was removed during surgery for histopathological analysis to verify the presence or not of arterial calcification. Two outcomes were considered: the presence of calcium deposition and the measurement of the IMT of the artery. The potential exposure variables were: age, chronic kidney disease aetiology, diagnosis time, systolic blood pressure (SBP), use of oral active vitamin D, homocysteine and C-reactive protein. Results No arterial calcification was observed in the studied sample. The median value of the IMT of the inferior epigastric artery was 166 mu m (interquartile range = 130-208). SBP standard deviation score and age were the only factors associated with this outcome. There was no statistical interaction between SBP and age with the IMT (P = 0.280). Conclusion Arterial calcification is rare in children and adolescents with end-stage renal disease. The factors associated with IMT were age and SBP. (AU)

• Processo FAPESP: 11/24030-0 - Frequência e fatores de risco para o acometimento arterial em crianças e adolescentes com doença renal crônica terminal
• Beneficiário: Paulo Cesar Koch Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular