| Full text | |
| Author(s): |
de Menezes, Fernanda L.
[1]
;
Koch-Nogueira, Paulo C.
[1]
;
do Val, Maria L. D. M.
[1]
;
Pestana, Jose O. M.
[2]
;
Jorgetti, Vanda
[3]
;
dos Reis, Marlene A.
[4]
;
dos Reis Monteiro, Maria L. G.
[4]
;
Leite, Heitor P.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Pediat, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Hosp Rim, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Internal Med, Sao Paulo - Brazil
[4] Univ Fed Triangulo Mineiro, Dept Pathol, Uberaba, MG - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | NEPHROLOGY; v. 24, n. 7, p. 696-702, JUL 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Aim To investigate if calcification and intimal media thickness (IMT) of arteries are present in children and adolescents with end-stage renal disease and to describe the risk factors associated with these alterations. Methods In an observational, cross-sectional prospective study, 68 patients were evaluated at the time of renal transplantation. A fragment of the inferior epigastric artery was removed during surgery for histopathological analysis to verify the presence or not of arterial calcification. Two outcomes were considered: the presence of calcium deposition and the measurement of the IMT of the artery. The potential exposure variables were: age, chronic kidney disease aetiology, diagnosis time, systolic blood pressure (SBP), use of oral active vitamin D, homocysteine and C-reactive protein. Results No arterial calcification was observed in the studied sample. The median value of the IMT of the inferior epigastric artery was 166 mu m (interquartile range = 130-208). SBP standard deviation score and age were the only factors associated with this outcome. There was no statistical interaction between SBP and age with the IMT (P = 0.280). Conclusion Arterial calcification is rare in children and adolescents with end-stage renal disease. The factors associated with IMT were age and SBP. (AU) | |
| FAPESP's process: | 11/24030-0 - Frequency and risk factors for arteriopathy in children and adolescents with end stage renal disease |
| Grantee: | Paulo Cesar Koch Nogueira |
| Support Opportunities: | Regular Research Grants |