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Effects of nutritional recovery on stress control, blood pressure and renal function

Grant number: 10/51237-2
Support Opportunities:Regular Research Grants
Duration: September 01, 2010 - February 28, 2013
Field of knowledge:Health Sciences - Nutrition - Malnutrition and Physiological Development
Principal Investigator:Ana Lydia Sawaya
Grantee:Ana Lydia Sawaya
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Previous studies of this research group and other researchers have shown that protein-energy malnutrition is linked to the development of non-communicable diseases in adulthood such as obesity, diabetes and hypertension. The physiological mechanisms involved in this association remain unknown. One hypothesis that has been discussed is that these diseases occur, among other factors, because of permanent changes in the programming of the hypothalamic-pituitary-adrenal axis, in which cortisol and catecholamines play a major role. It is known, through experimental studies in animals and humans that malnutrition in early life leads to increase in these hormones, which are responsible for controlling stress in the body. But there is no published data on the effect of nutritional rehabilitation and their eventual standardization. The objectives of this study are to evaluate the effects of nutritional recovery on stress management, blood pressure and renal function. Will be assessed the baseline concentration after stressor stimulus and relaxation of cortisol and salivary alpha-amylase, and blood pressure. We will also measure the basal activity of the angiotensin-converting enzyme, the concentration of plasma catecholamines and renal microalbumin. The groups will consist of: a) children and adolescents recovered from malnutrition who received nutritional intervention in the Center for Recovery and Nutritional Education (CREN) and that after treatment of a minimum of six months presented a value of Z score > -1.5 weight-for-age and height-for-age, b) malnourished children and adolescents before treatment with values of Z-score < -1.5 for weight-for-age and/or height-for age and c) middle class individuals with normal nutritional status with weight-for-age and height for-age Z scores > -0.5. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINS, VINICIUS J. B.; NEVES, ANDREA P. O.; GARCIA, MARCIA C.; SPADARI, REGINA C.; CLEMENTE, ANA PAULA G.; DE ALBUQUERQUE, MARIA P.; HOFFMAN, DANIEL J.; SAWAYA, ANA L.. Normal cortisol response to cold pressor test, but lower free thyroxine, after recovery from undernutrition. BRITISH JOURNAL OF NUTRITION, v. 115, n. 1, p. 14-23, . (10/51237-2)
MARTINS, VINICIUS J. B.; NEVES, ANDREA P. O.; FRANCO, MARIA DO C. P.; CLEMENTE, ANA P. G.; SAWAYA, ANA L.. Impact of nutritional recovery with linear growth on the concentrations of adipokines in undernourished children living in Brazilian slums. BRITISH JOURNAL OF NUTRITION, v. 112, n. 6, p. 937-944, . (10/51237-2)
MARTINS, VINICIUS J. B.; SESSO, RICARDO; CLEMENTE, ANA P. G.; FERNANDES, MARIANA B. F.; SAWAYA, ANA L.. Albuminuria, renal function and blood pressure in undernourished children and recovered from undernutrition. Pediatric Nephrology, v. 32, n. 9, p. 1555-1563, . (10/51237-2)

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