Consumption of Brazil nuts with high selenium levels increased inflammation biomarkers in obese women: A randomized controlled trial

Autor(es)

Silva Duarte, Graziela Biude ^[1] ; Reis, Bruna Zavarize ^[1] ; Rogero, Marcelo Macedo ^{[2, 3]} ; Vargas-Mendez, Ernesto ^[4] ; Barbosa Junior, Fernando ^[5] ; Cercato, Cintia ^[6] ; Franciscato Cozzolino, Silvia Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil

^[3] Sao Paulo Res Fdn, Food Res Ctr FoRC, CEPID FAPESP, Res Innovat & Disseminat Ctr, Sao Paulo - Brazil

^[4] Univ Costa Rica, Sch Med, Dept Biochem, San Jose - Costa Rica

^[5] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto, SP - Brazil

^[6] Univ Sao Paulo, Clin Hosp, Sch Med, Div Endocrinol & Metab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 63-64, p. 162-168, JUL-AUG 2019.
• Citações Web of Science: 1

Resumo

Objective: Increased inflammatory response is an important factor in the pathophysiology of obesity. The mineral selenium (Se), of which one of the main food sources is the Brazil nut, has important antioxidant and anti-inflammatory functions through the action of selenoproteins. Thus, the evaluation of the influence of this micronutrient in this context is of great relevance. The aim of this study was to evaluate the effects of Brazil nut intake with high Se concentrations on inflammatory biomarkers and its relation to Se status in obese women. Methods: A randomized controlled clinical trial was carried out with 55 women recruited at Clinical Hospital in Sao Paulo, Brazil. Patients were randomly assigned to either the Brazil nut group (BN) or the control group (CO) and followed up for 2 mo. The BN group consumed 1 unit/d of Brazil nuts (similar to 1261 mu g/Se); the CO group did not receive any intervention. At baseline and after 2 mo, analysis of biochemical parameters related to Se status, oxidative stress, and inflammatory biomarkers were performed. Results: At baseline, both groups did not present Se deficiency. In the BN group, a significant increase (P < 0.05) in all Se biomarkers and in gene expression of several proinflammatory parameters (interleukin-6, tumor necrosis factor-a, and Toll-like receptors 2 and 4) were observed after the intervention period. No changes were observed for the CO group. Conclusion: Although there were no changes in plasma inflammatory biomarkers levels, a significant increase in gene expression may be an indication of a proinflammatory stimulus in obesity, induced by the consumption of Brazil nuts with high Se levels. (C) 2019 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 15/02906-2 - Efeito da suplementação com castanha-do-brasil (Bertholettia excelsa H.B.K.) sobre a inflamação, o estresse oxidativo e a expressão de Selenoproteina P e microRNAs em mulheres obesas
• Beneficiário: Silvia Maria Franciscato Cozzolino
• Modalidade de apoio: Auxílio à Pesquisa - Regular