Sarcopenia as an independent prognostic factor in patients with metastatic colorectal cancer: A retrospective evaluation

Autor(es)

da Cunha, Lorena Pires ^[1] ; Silveira, Marina Nogueira ^[1] ; Santos Mendes, Maria Carolina ^[1] ; Costa, Felipe Osorio ^[1] ; Macedo, Ligia Traldi ^[1] ; de Siqueira, Nadia Sclearuc ^[1] ; Campello Carvalheira, Jose Barreto ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Div Oncol, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL NUTRITION ESPEN; v. 32, p. 107-112, AUG 2019.
• Citações Web of Science: 3

Resumo

Background \& aims: Sarcopenia has been associated with poor prognosis in a number of malignancies. However, whether sarcopenia is associated with colorectal cancer (CRC) prognosis in a metastatic setting remains unclear. The aim of the study presented was to evaluate the impact of sarcopenia on progression-free survival (PFS) and overall survival (OS) in patients with metastatic CRC. Methods: We retrospectively studied 72 patients with stage IV CRC treated at the University of Campinas between 2009 and 2015. Computed tomography images were analyzed to assess body composition. The Kaplan-Meier and multivariate Cox proportional hazards regression were used for survival analysis and to evaluate the influence of sarcopenia on PFS and OS. Results: Median PFS for sarcopenic patients (n = 32) was 7.2 months, which was significantly different from non-sarcopenic patients (n = 40), which was 15.2 months (hazard ratio {[}HR]: 1.78; 95% confidence interval {[}CI], 1.00-3.14; P = 0.048). Sarcopenia was also a significant predictor of OS. Median OS for sarcopenic patients was 12.5 months versus 36.7 months for non-sarcopenic patients (HR: 1.86; 95% CI, 1.02-3.38; P = 0.043), after adjustment for number of metastatic lesions, metastasectomy, and performance status. Conclusions: Sarcopenia was associated with worse CRC PFS and OS. These findings require prospective trials to validate this association. (C) 2019 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 10/19503-4 - S-nitrosação de proteínas envolvidas nas vias de sinalização da insulina e leptina em hipotálamo de roedores obesos: um novo mecanismo na gênese da obesidade
• Beneficiário: José Barreto Campello Carvalheira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs