Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area

Autor(es):Mostrar menos -

De Pretto, Lucas R. ^{[1, 2]} ; Moult, Eric M. ^[1] ; Alibhai, A. Yasin ^[3] ; Carrasco-Zevallos, Oscar M. ^[1] ; Chen, Siyu ^[1] ; Lee, ByungKun ^[1] ; Witkin, Andre J. ^[3] ; Baumal, Caroline R. ^[3] ; Reichel, Elias ^[3] ; de Freitas, Anderson Zanardi ^[2] ; Duker, Jay S. ^[3] ; Waheed, Nadia K. ^[3] ; Fujimoto, James G. ^[1]

Afiliação do(s) autor(es)

^[1] MIT, Dept Elect Engn & Comp Sci, Res Lab Elect, 77 Massachusetts Ave, Cambridge, MA 02139 - USA

^[2] Nucl & Energy Res Inst, IPEN CNEN SP, Sao Paulo - Brazil

^[3] Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 - USA

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 9, JUN 24 2019.
• Citações Web of Science: 1

Resumo

The recent clinical adoption of optical coherence tomography (OCT) angiography (OCTA) has enabled non-invasive, volumetric visualization of ocular vasculature at micron-scale resolutions. Initially limited to 3 mm x 3 mm and 6 mm x 6 mm fields-of-view (FOV), commercial OCTA systems now offer 12 mm x 12 mm, or larger, imaging fields. While larger FOVs promise a more complete visualization of retinal disease, they also introduce new challenges to the accurate and reliable interpretation of OCTA data. In particular, because of vignetting, wide-field imaging increases occurrence of low-OCT-signal artifacts, which leads to thresholding and/or segmentation artifacts, complicating OCTA analysis. This study presents theoretical and case-based descriptions of the causes and effects of low-OCT-signal artifacts. Through these descriptions, we demonstrate that OCTA data interpretation can be ambiguous if performed without consulting corresponding OCT data. Furthermore, using wide-field non-perfusion analysis in diabetic retinopathy as a model widefield OCTA usage-case, we show how qualitative and quantitative analysis can be confounded by low-OCT-signal artifacts. Based on these results, we suggest methods and best-practices for preventing and managing low-OCT-signal artifacts, thereby reducing errors in OCTA quantitative analysis of non-perfusion and improving reproducibility. These methods promise to be especially important for longitudinal studies detecting progression and response to therapy. (AU)

• Processo FAPESP: 15/15775-3 - Algoritmo para análise de autocorrelação de sinal de tomografia por coerência óptica para acompanhamento de fluxo sanguíneo em camundongos com síndrome metabólica
• Beneficiário: Lucas Ramos de Pretto
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/17342-0 - Aplicação de técnicas de análise de speckle em OCT para diagnóstico óptico in vivo.
• Beneficiário: Lucas Ramos de Pretto
• Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado