Lipid-based carriers for the delivery of local anesthetics

Autor(es)

de Araujo, Daniele Ribeiro ^[1] ; de Morais Ribeiro, Ligia Nunes ^[2] ; de Paula, Eneida ^[2]

Afiliação do(s) autor(es)

^[1] Fed Univ ABC, Human & Nat Sci Ctr, Sao Paulo - Brazil

^[2] Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Expert Opinion on Drug Delivery; v. 16, n. 7 JUN 2019.
• Citações Web of Science: 0

Resumo

Introduction: There is a clinical need for pharmaceutical dosage forms devised to prolong the acting time of local anesthetic (LA) agents or to reduce their toxicity. Encapsulation of LA in drug delivery systems (DDSs) can provide long-term anesthesia for inpatients (e.g. in immediate postsurgical pain control, avoiding the side effects from systemic analgesia) and diminished systemic toxicity for outpatients (in ambulatory/dentistry procedures). The lipid-based formulations described here, such as liposomes, microemulsions, and lipid nanoparticles, have provided several nanotechnological advances and therapeutic alternatives despite some inherent limitations associated with the fabrication processes, costs, and preclinical evaluation models. Areas covered: A description of the currently promising lipid-based carriers, including liposomes, microemulsions, and nanostructured lipid carriers, followed by a systematic review of the existing lipid-based formulations proposed for LA. Trends in the research of these LA-in-DDS are then exposed, from the point of view of administration route and alternatives for non-traditionally administered LA molecules. Expert opinion: Considering the current state and potential future developments in the field, we discuss the reasons for why dozens of formulations published every year fail to reach clinical trials; only one lipid-based formulation for the delivery of local anesthetic (Exparel (R)) has been approved so far. (AU)

• Processo FAPESP: 14/25372-0 - Desenvolvimento de carreadores lipídicos nanoestruturados para encapsulação de anestésicos locais processados em matrizes biopoliméricas para aplicação tópica em mucosa oral
• Beneficiário: Lígia Nunes de Morais Ribeiro
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/14457-5 - Carreadores baseados em lipídios (SLN/NLC e lipossomas com gradiente iônico) como estratégia para aumentar a encapsulação e a potência de anestésicos locais
• Beneficiário: Eneida de Paula
• Linha de fomento: Auxílio à Pesquisa - Temático