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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil

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Autor(es):
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Leal, Elcio [1] ; Luchs, Adriana [2] ; de Padua Milagres, Flavio Augusto [3, 4, 5, 6] ; Komninakis, Shirley Vasconcelos [7, 8] ; Gill, Danielle Elise [9] ; Brito Sayao Lobato, Marcia Cristina Alves [4, 6] ; Brustulin, Rafael [4, 5, 6] ; das Chagas, Rogerio Togisaki [4, 6] ; Neves dos Santos Abrao, Maria de Fatima [4, 6] ; de Deus Alves Soares, Cassia Vitoria [4, 6] ; Villanova, Fabiola [1] ; Witkin, Steven S. [9, 10] ; Deng, Xutao [11, 12] ; Sabino, Ester Cerdeira [3, 9] ; Delwart, Eric [11, 12] ; da Costa, Antonio Charlys [9]
Número total de Autores: 16
Afiliação do(s) autor(es):
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[1] Univ Fed Para, Inst Ciencias Biol, BR-66075000 Belem, Para - Brazil
[2] Adolfo Lutz Inst, Ctr Virol, Lab Doencas Enter, BR-01246000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, LIM-46, BR-01246903 Sao Paulo - Brazil
[4] Secretaria Saude Tocantins, BR-77453000 Tocantins - Brazil
[5] Univ Fed Tocantins, Inst Ciencias Biol, BR-77001090 Tocantins - Brazil
[6] Lab Cent Saude Publ Tocantins LACEN TO, BR-77016330 Tocantins - Brazil
[7] Fac Med ABC, BR-09060870 Santo Andre - Brazil
[8] Univ Fed Sao Paulo, Lab Retrovirol, BR-04023062 Sao Paulo - Brazil
[9] Univ Sao Paulo, Inst Med Trop, BR-05403000 Sao Paulo - Brazil
[10] Weill Cornell Med, Dept Obstet & Gynecol, 1300 York Ave, New York, NY 10065 - USA
[11] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 - USA
[12] Blood Syst Res Inst, San Francisco, CA 94143 - USA
Número total de Afiliações: 12
Tipo de documento: Artigo Científico
Fonte: Viruses-Basel; v. 11, n. 6 JUN 2019.
Citações Web of Science: 0
Resumo

We characterized the 24 nearly full-length genomes of human parechoviruses (PeV) from children in the north of Brazil. The initial phylogenetic analysis indicated that 17 strains belonged to genotype 1, 5 to genotype 4, and 1 to genotype 17. A more detailed analysis revealed a high frequency of recombinant strains (58%): A total of 14 of our PeV-As were chimeric, with four distinct recombination patterns identified. Five strains were composed of genotypes 1 and 5 (Rec1/5); five strains shared a complex mosaic pattern formed by genotypes 4, 5, and 17 (Rec4/17/5); two strains were composed of genotypes 1 and 17 (Rec1/17); and two strains were composed of genotype 1 and an undetermined strain (Rec1/und). Coalescent analysis based on the Vp1 gene, which is free of recombination, indicated that the recombinant strains most likely arose in this region approximately 30 years ago. They are present in high frequencies and are circulating in different small and isolated cities in the state of Tocantins. Further studies will be needed to establish whether the detected recombinant strains have been replacing parental strains or if they are co-circulating in distinct frequencies in Tocantins. (AU)

Processo FAPESP: 15/12944-9 - Investigando a evolução de cepas animais de rotavírus infectando humanos
Beneficiário:Adriana Luchs
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 17/00021-9 - Metagenômica viral da dengue, Chikungunya e Zika: acompanhar, explicar e prever a transmissão e distribuição espaço-temporal no Brasil
Beneficiário:Antonio Charlys da Costa
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/01735-2 - Metagenômica viral de dengue, Chikungunya e Zika vírus: acompanhar, explicar e prever a transmissão e distribuição espaço-temporal no Brasil
Beneficiário:Ester Cerdeira Sabino
Linha de fomento: Auxílio à Pesquisa - Regular