General model for depth-resolved estimation of the optical attenuation coefficients in optical coherence tomography

Autor(es)

Amaral, Marcello M. ^{[1, 2]} ; Zezell, Denise M. ^[1] ; Monte, Adamo F. G. ^[3] ; de Cara, Ana C. B. ^[1] ; Araujo, Jeann C. R. ^[3] ; Antunes, Andrea ^[3] ; Freitas, Anderson Z. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, IPEN, CNEN SP, Ave Prof Lineu Prestes 2242, Sao Paulo - Brazil

^[2] Univ Brasil, Inst Cient & Tecnol, Sao Paulo - Brazil

^[3] Univ Fed Uberlandia, Inst Fis, Uberlandia, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biophotonics; v. 12, n. 10 JULY 2019.
• Citações Web of Science: 0

Resumo

We present the proof of concept of a general model that uses the tissue sample transmittance as input to estimate the depth-resolved attenuation coefficient of tissue samples using optical coherence tomography (OCT). This method allows us to obtain an image of tissue optical properties instead of intensity contrast, guiding diagnosis and tissues differentiation, extending its application from thick to thin samples. The performance of our method was simulated and tested with the assistance of a home built single-layered and multilayered phantoms (similar to 100 mu m each layer) with known attenuation coefficient on the range of 0.9 to 2.32 mm(-1). It is shown that the estimated depth-resolved attenuation coefficient recovers the reference values, measured by using an integrating sphere followed by the inverse adding doubling processing technique. That was corroborated for all situations when the correct transmittance value is used with an average difference of 7%. Finally, we applied the proposed method to estimate the depth-resolved attenuation coefficient for a thin biological sample, demonstrating the ability of our method on real OCT images. (AU)

• Processo FAPESP: 10/03123-8 - Avaliação do processo de desenvolvimento de desmineralização em esmalte dental utilizando a técnica de tomografia por coerência óptica
• Beneficiário: Ana Claudia Ballet de Cara
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 17/50332-0 - Capacitação científica, tecnológica e em infraestrutura em radiofármacos, radiações e empreendedorismo a serviço da saúde (PDIp)
• Beneficiário: Marcelo Linardi
• Modalidade de apoio: Auxílio à Pesquisa - Programa Modernização de Institutos Estaduais de Pesquisa
• Processo FAPESP: 05/51689-2 - Centro de Pesquisa em Óptica e Fotônica - UNICAMP (CEPOF-UNICAMP)
• Beneficiário: Hugo Luis Fragnito
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs