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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

General model for depth-resolved estimation of the optical attenuation coefficients in optical coherence tomography

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Author(s):
Amaral, Marcello M. [1, 2] ; Zezell, Denise M. [1] ; Monte, Adamo F. G. [3] ; de Cara, Ana C. B. [1] ; Araujo, Jeann C. R. [3] ; Antunes, Andrea [3] ; Freitas, Anderson Z. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, IPEN, CNEN SP, Ave Prof Lineu Prestes 2242, Sao Paulo - Brazil
[2] Univ Brasil, Inst Cient & Tecnol, Sao Paulo - Brazil
[3] Univ Fed Uberlandia, Inst Fis, Uberlandia, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Biophotonics; v. 12, n. 10 JULY 2019.
Web of Science Citations: 0
Abstract

We present the proof of concept of a general model that uses the tissue sample transmittance as input to estimate the depth-resolved attenuation coefficient of tissue samples using optical coherence tomography (OCT). This method allows us to obtain an image of tissue optical properties instead of intensity contrast, guiding diagnosis and tissues differentiation, extending its application from thick to thin samples. The performance of our method was simulated and tested with the assistance of a home built single-layered and multilayered phantoms (similar to 100 mu m each layer) with known attenuation coefficient on the range of 0.9 to 2.32 mm(-1). It is shown that the estimated depth-resolved attenuation coefficient recovers the reference values, measured by using an integrating sphere followed by the inverse adding doubling processing technique. That was corroborated for all situations when the correct transmittance value is used with an average difference of 7%. Finally, we applied the proposed method to estimate the depth-resolved attenuation coefficient for a thin biological sample, demonstrating the ability of our method on real OCT images. (AU)

FAPESP's process: 10/03123-8 - Development process evaluation of dental enamel demineralization using the optical coherence tomography
Grantee:Ana Claudia Ballet de Cara
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 17/50332-0 - Scientific, technological and infrastructure qualification in radiopharmaceuticals, radiation and entrepreneurship for health purposes (PDIp)
Grantee:Marcelo Linardi
Support Opportunities: Research Grants - State Research Institutes Modernization Program
FAPESP's process: 05/51689-2 - Optics and Photonics Research Center at UNICAMP
Grantee:Hugo Luis Fragnito
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC