| Full text | |
| Author(s): |
Amaral, Marcello M.
[1, 2]
;
Zezell, Denise M.
[1]
;
Monte, Adamo F. G.
[3]
;
de Cara, Ana C. B.
[1]
;
Araujo, Jeann C. R.
[3]
;
Antunes, Andrea
[3]
;
Freitas, Anderson Z.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, IPEN, CNEN SP, Ave Prof Lineu Prestes 2242, Sao Paulo - Brazil
[2] Univ Brasil, Inst Cient & Tecnol, Sao Paulo - Brazil
[3] Univ Fed Uberlandia, Inst Fis, Uberlandia, MG - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of Biophotonics; v. 12, n. 10 JULY 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
We present the proof of concept of a general model that uses the tissue sample transmittance as input to estimate the depth-resolved attenuation coefficient of tissue samples using optical coherence tomography (OCT). This method allows us to obtain an image of tissue optical properties instead of intensity contrast, guiding diagnosis and tissues differentiation, extending its application from thick to thin samples. The performance of our method was simulated and tested with the assistance of a home built single-layered and multilayered phantoms (similar to 100 mu m each layer) with known attenuation coefficient on the range of 0.9 to 2.32 mm(-1). It is shown that the estimated depth-resolved attenuation coefficient recovers the reference values, measured by using an integrating sphere followed by the inverse adding doubling processing technique. That was corroborated for all situations when the correct transmittance value is used with an average difference of 7%. Finally, we applied the proposed method to estimate the depth-resolved attenuation coefficient for a thin biological sample, demonstrating the ability of our method on real OCT images. (AU) | |
| FAPESP's process: | 10/03123-8 - Development process evaluation of dental enamel demineralization using the optical coherence tomography |
| Grantee: | Ana Claudia Ballet de Cara |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/50332-0 - Scientific, technological and infrastructure qualification in radiopharmaceuticals, radiation and entrepreneurship for health purposes (PDIp) |
| Grantee: | Marcelo Linardi |
| Support Opportunities: | Research Grants - State Research Institutes Modernization Program |
| FAPESP's process: | 05/51689-2 - Optics and Photonics Research Center at UNICAMP |
| Grantee: | Hugo Luis Fragnito |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |