Caffeoylquinic Acids: Separation Method, Antiradical Properties and Cytotoxicity

Autor(es)

Indy Tamayose, Cinthia ^[1] ; dos Santos, Evelyne A. ^[2] ; Roque, Nadia ^[3] ; Costa-Lotufo, Leticia V. ^[2] ; Pena Ferreira, Marcelo J. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, BR-05508090 Sao Paulo - Brazil

^[3] Univ Fed Bahia, Inst Biol, BR-40170290 Salvador, BA - Brazil

^[4] Univ Sao Paulo, Inst Biociencias, Dept Bot, BR-05508090 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRY & BIODIVERSITY; v. 16, n. 7 JUL 2019.
• Citações Web of Science: 1

Resumo

Twelve chlorogenic acid derivatives and two flavones were isolated from Moquiniastrum floribundum (Asteraceae, other name: Gochnatia floribunda). Compounds were evaluated in relation to their cytotoxicity and antiradical properties. Cytotoxicity was not observed for compounds, however, chlorogenic acid derivatives showed antiradical activity and were more active than the Trolox standard. Quinic acid esterified with caffeoyl group at C-4 position showed higher antiradical activity compared to acylation at C-3 or C-5 positions. Additional caffeoyl groups esterified in quinic acid increase the antiradical activity observed for 4-caffeoylquinic acid. Excepted to 3,4-dicaffeoylquinic acid methyl ester, methyl ester derivatives show higher capacity of trapping radicals than their respective acids. Consequently, the presence of caffeoyl group at C-4 position of quinic acid is suggested as fundamental to obtain the highest antiradical activity. (AU)

• Processo FAPESP: 15/17177-6 - Abordagem integrada na prospecção sustentável de produtos naturais marinhos: da diversidade a substâncias anticâncer
• Beneficiário: Leticia Veras Costa Lotufo
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/21593-2 - Baccharis L. (Asteraceae) e fungos endofíticos associados: metabólitos secundários e atividades biológicas
• Beneficiário: Marcelo José Pena Ferreira
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/20932-8 - Estudo fitoquímico, quimiossistemático e atividades biológicas de espécies de Moquiniastrum e Richterago
• Beneficiário: Cinthia Indy Tamayose
• Linha de fomento: Bolsas no Brasil - Doutorado