| Full text | |
| Author(s): |
Indy Tamayose, Cinthia
[1]
;
dos Santos, Evelyne A.
[2]
;
Roque, Nadia
[3]
;
Costa-Lotufo, Leticia V.
[2]
;
Pena Ferreira, Marcelo J.
[4]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, BR-05508090 Sao Paulo - Brazil
[3] Univ Fed Bahia, Inst Biol, BR-40170290 Salvador, BA - Brazil
[4] Univ Sao Paulo, Inst Biociencias, Dept Bot, BR-05508090 Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | CHEMISTRY & BIODIVERSITY; v. 16, n. 7 JUL 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Twelve chlorogenic acid derivatives and two flavones were isolated from Moquiniastrum floribundum (Asteraceae, other name: Gochnatia floribunda). Compounds were evaluated in relation to their cytotoxicity and antiradical properties. Cytotoxicity was not observed for compounds, however, chlorogenic acid derivatives showed antiradical activity and were more active than the Trolox standard. Quinic acid esterified with caffeoyl group at C-4 position showed higher antiradical activity compared to acylation at C-3 or C-5 positions. Additional caffeoyl groups esterified in quinic acid increase the antiradical activity observed for 4-caffeoylquinic acid. Excepted to 3,4-dicaffeoylquinic acid methyl ester, methyl ester derivatives show higher capacity of trapping radicals than their respective acids. Consequently, the presence of caffeoyl group at C-4 position of quinic acid is suggested as fundamental to obtain the highest antiradical activity. (AU) | |
| FAPESP's process: | 14/20932-8 - PHYTOCHEMISTRY, CHEMOSYSTEMATIC STUDY AND BIOLOGICAL ACTIVITIES OF Moquiniastrum AND Richterago SPECIES |
| Grantee: | Cinthia Indy Tamayose |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/17177-6 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds |
| Grantee: | Leticia Veras Costa Lotufo |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 14/21593-2 - Baccharis L. (Asteraceae) and endophytic fungi: secondary metabolites and biological activities |
| Grantee: | Marcelo José Pena Ferreira |
| Support Opportunities: | Regular Research Grants |