Abstract
Brazilian marine ecosystems have great strategic importance for the country. Nonetheless, the sustainable use of marine natural resources is still a challenging endeavor. In fact, in many cases we even ignore what are the resources available, in view of the lack of information concerning biodiversity and ecosystems functioning. Thus, this project was conceived for the development of an integrative research strategy, in order to establish a new paradigm for bioprospection.I. Intellectual Merit: This proposal aims at providing an integrative approach to understand how diversity at different organization levels interact and may drive the production of secondary metabolites with interesting pharmacological properties, especially those related to cancer therapy. In particular, the leading premise is combining different approaches, including culture dependent (bioactivity and target-guided) and independent (metabolomics and metagenomics) studies, and also bring to context the underlying processes driving the biodiversity organization and functioning. The elected targets, the anti-senescence transcription factors Tbx2 and Tbx3, are involved in the tumorigenic process, but with no exogenous modulator described so far. The potential identification of new natural molecules from the Brazilian biodiversity targeting Tbx2 and Tbx3 bring to this project a strong innovative potential.II. Broader Impacts: Within the paradigm of sustainable use of natural resources, a core value in all diversity conservation programs, the integrative approach herein presented should be used for a comprehensive evaluation of emerging patterns driving diversity in different levels: from genes to secondary metabolites. III. Integration: The proposed integrative approach proposed brings together scientists from different research areas working under a common set of objectives, sharing data through electronic tools and brewing together ideas to promote knowledge on biodiversity conservation and sustainable use. It is worth mentioning, especially, that this project is essentially multidisciplinary and with great potential for innovation, as it is inserted in an extremely promising area, motivated by a sustainable exploration of marine resources in order to identify new biotechnological products, as well as to legitimize new anticancer molecular targets. (AU)
Scientific publications
(19)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VICARI, HUGO PASSOS;
LIMA, KELI;
GOMES, RALPH DA COSTA;
FERNANDES, DANIARA CRISTINA;
LIPRERI DA SILVA, JEAN CARLOS;
RODRIGUES JUNIOR, MANOEL TRINDADE;
BARROSO DE OLIVEIRA, ALINE SILVA;
DOS SANTOS, RICARDO NASCIMENTO;
ANDRICOPULO, ADRIANO DEFINI;
COELHO, FERNANDO;
COSTA-LOTUFO, LETICIA VERAS;
MACHADO-NETO, JOAO AGOSTINHO.
Synthetic cyclopenta [b] indoles exhibit antineoplastic activity by targeting microtubule dynamics in acute myeloid leukemia cells.
European Journal of Pharmacology,
v. 894,
MAR 5 2021.
Web of Science Citations: 0.
TANGERINA, MARCELO M. P.;
FURTADO, LUCIANA COSTA;
LEITE, VIDA M. B.;
BAUERMEISTER, ANELIZE;
VELASCO-ALZATE, KAREN;
JIMENEZ, PAULA C.;
GARRIDO, LEANDRO M.;
PADILLA, GABRIEL;
LOPES, NORBERTO P.;
COSTA-LOTUFO, LETICIA V.;
PENA FERREIRA, MARCELO J.
Metabolomic study of marine Streptomyces sp.: Secondary metabolites and the production of potential anticancer compounds.
PLoS One,
v. 15,
n. 12
DEC 21 2020.
Web of Science Citations: 0.
GIACONE, V, DANIELA;
DARTORA, VANESSA F. M. C.;
DE MATOS, JENYFFER K. R.;
PASSOS, JULIA S.;
MIRANDA, DANIEL A. G.;
DE OLIVEIRA, ERICA A.;
SILVEIRA, EDILBERTO R.;
COSTA-LOTUFO, V, LETICIA;
MARIA-ENGLER, SILVYA S.;
LOPES, LUCIANA B.
Effect of nanoemulsion modification with chitosan and sodium alginate on the topical delivery and efficacy of the cytotoxic agent piplartine in 2D and 3D skin cancer models.
International Journal of Biological Macromolecules,
v. 165,
n. A,
p. 1055-1065,
DEC 15 2020.
Web of Science Citations: 2.
BRANCO, PAOLA C.;
PONTES, CRISTINE A.;
REZENDE-TEIXEIRA, PAULA;
AMENGUAL-RIGO, PEP;
ALVES-FERNANDES, DEBORA K.;
MARIA-ENGLER, SILVYA STUCHI;
DA SILVA, ALISON B.;
PESSOA, OTILIA DEUSDENIA L.;
JIMENEZ, PAULA C.;
MOLLASALEHI, NILOUFAR;
CHAPMAN, ELI;
GUALLAR, VICTOR;
MACHADO-NETO, JOAO.;
COSTA-LOTUFO, LETICIA V.
Survivin modulation in the antimelanoma activity of prodiginines.
European Journal of Pharmacology,
v. 888,
DEC 5 2020.
Web of Science Citations: 0.
WILKE, V, DIEGO;
JIMENEZ, PAULA C.;
BRANCO, PAOLA C.;
REZENDE-TEIXEIRA, PAULA;
TRINDADE-SILVA, AMARO E.;
BAUERMEISTER, ANELIZE;
LOPES, NORBERTO PEPORINE;
COSTA-LOTUFO, V, LETICIA.
Anticancer Potential of Compounds from the Brazilian Blue Amazon.
Planta Medica,
v. 87,
n. 01/02
NOV 2020.
Web of Science Citations: 0.
ELIAS GODOY CARLOS, JORGE ANTONIO;
LIMA, KELI;
COELHO-SILVA, JUAN LUIZ;
ALVES-PAIVA, RAQUEL DE MELO;
MORENO, NATALIA CESTARI;
VICARI, HUGO PASSOS;
DE SOUZA SANTOS, FABIO PIRES;
HAMERSCHLAK, NELSON;
COSTA-LOTUFO, LETICIA VERAS;
TRAINA, FABIOLA;
MACHADO-NETO, JOAO AGOSTINHO.
Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia.
CELLULAR ONCOLOGY,
v. 43,
n. 6
AUG 2020.
Web of Science Citations: 0.
SAHM, BIANCA DEL B.;
PERES, JADE;
REZENDE-TEIXEIRA, PAULA;
SANTOS, EVELYNE A.;
BRANCO, PAOLA C.;
BAUERMEISTER, ANELIZE;
KIMANI, SERAH;
MOREIRA, EDUARDA A.;
BISI-ALVES, RENATA;
BELLIS, CLAIRE;
MLAZA, MIHLALI;
JIMENEZ, PAULA C.;
LOPES, NORBERTO P.;
MACHADO-SANTELLI, GLAUCIA M.;
PRINCE, SHARON;
COSTA-LOTUFO, V, LETICIA.
Targeting the Oncogenic TBX2 Transcription Factor With Chromomycins.
FRONTIERS IN CHEMISTRY,
v. 8,
MAR 3 2020.
Web of Science Citations: 0.
BARROSO, CRISTIANE XEREZ;
PEREIRA DE FREITAS, JOAO EDUARDO;
MATTHEWS-CASCON, HELENA;
ARRUDA BEZERRA, LUIS ERNESTO;
DA CRUZ LOTUFO, TITO MONTEIRO.
Molecular evidences confirm the taxonomic separation of two sympatric congeneric species (Mollusca, Gastropoda, Neritidae, Neritina).
ZOOKEYS,
n. 904,
p. 117-130,
JAN 16 2020.
Web of Science Citations: 0.
JIMENEZ, PAULA C.;
WILKE, DIEGO V.;
BRANCO, PAOLA C.;
BAUERMEISTER, ANELIZE;
REZENDE-TEIXEIRA, PAULA;
GAUDENCIO, SUSANA P.;
COSTA-LOTUFO, LETICIA V.
Enriching cancer pharmacology with drugs of marine origin.
British Journal of Pharmacology,
v. 177,
n. 1,
p. 3-27,
JAN 2020.
Web of Science Citations: 1.
PINTO, FRANCISCO C. L.;
SILVEIRA, EDILBERTO R.;
VASCONCELOS, ANA CAROLINE L.;
FLORENCIO, KATHARINE G. D.;
OLIVEIRA, FRANCISCA A. S.;
SAHM, BIANCA B.;
COSTA-LOTUFO, V, LETICIA;
BAUERMEISTER, ANELIZE;
LOPES, NORBERTO P.;
WILKE, V, DIEGO;
PESSOA, OTILIA D. L.
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum.
Journal of the Brazilian Chemical Society,
v. 31,
n. 1,
p. 143-152,
JAN 2020.
Web of Science Citations: 0.
VELASCO-ALZATE, KAREN Y.;
BAUERMEISTER, ANELIZE;
TANGERINA, MARCELO M. P.;
LOTUFO, TITO M. C.;
FERREIRA, MARCELO J. P.;
JIMENEZ, PAULA C.;
PADILLA, GABRIEL;
LOPES, NORBERTO P.;
COSTA-LOTUFO, LETICIA V.
Marine Bacteria from Rocas Atoll as a Rich Source of Pharmacologically Active Compounds.
MARINE DRUGS,
v. 17,
n. 12
DEC 2019.
Web of Science Citations: 0.
DE ALMEIDA, LARISSA COSTA;
BAUERMEISTER, ANELIZE;
REZENDE-TEIXEIRA, PAULA;
DOS SANTOS, EVELYNE ALVES;
BERALDO DE MORAES, LUIZ ALBERTO;
MACHADO-NETO, JOAO AGOSTINHO;
COSTA-LOTUFO, LETICIA VERAS.
Pradimicin-IRD exhibits antineoplastic effects by inducing DNA damage in colon cancer cells.
Biochemical Pharmacology,
v. 168,
p. 38-47,
OCT 2019.
Web of Science Citations: 1.
MEDINA, REBECA P.;
ARAUJO, ANGELA R.;
BATISTA JR, JOAO M.;
CARDOSO, CARMEN L.;
SEIDL, CLAUDIA;
VILELA, ADRIANA F. L.;
DOMINGOS, V, HELORI;
COSTA-LOTUFO, V, LETICIA;
ANDERSEN, RAYMOND J.;
SILVA, DULCE H. S.
Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis - Falkenbergia stage.
SCIENTIFIC REPORTS,
v. 9,
AUG 23 2019.
Web of Science Citations: 1.
DA SILVA, ALISON B.;
SILVEIRA, EDILBERTO R.;
WILKE, DIEGO V.;
FERREIRA, ELHTON G.;
COSTA-LOTUFO, LETICIA V.;
TORRES, MARIA CONCEICAO M.;
AYALA, ALEJANDRO PEDRO;
COSTA, WENDELL S.;
CANUTO, KIRLEY M.;
DE ARAUJO-NOBRE, ALYNE R.;
ARAUJO, ANA JERSIA;
MARINHO FILHO, JOSE DELANO B.;
PESSOA, OTILIA DEUSDENIA L.
Antibacterial Salinaphthoquinones from a Strain of the Bacterium Salinispora arenicola Recovered from the Marine Sediments of St. Peter and St. Paul Archipelago, Brazil.
Journal of Natural Products,
v. 82,
n. 7,
p. 1831-1838,
JUL 2019.
Web of Science Citations: 4.
BAUERMEISTER, ANELIZE;
VELASCO-ALZATE, KAREN;
DIAS, TIAGO;
MACEDO, HELENA;
FERREIRA, ELTHON G.;
JIMENEZ, PAULA C.;
LOTUFO, TITO M. C.;
LOPES, NORBERTO P.;
GAUDENCIO, SUSANA P.;
COSTA-LOTUFO, V, LETICIA.
Metabolomic Fingerprinting of Salinispora From Atlantic Oceanic Islands.
FRONTIERS IN MICROBIOLOGY,
v. 9,
DEC 11 2018.
Web of Science Citations: 3.