Emerging Aspects of the Body Composition, Bone Marrow Adipose Tissue and Skeletal Phenotypes in Type 1 Diabetes Mellitus

Autor(es):Mostrar menos -

Carvalho, Adriana L. ^[1] ; Massaro, Bianca ^[1] ; e Silva, Luciana T. P. ^[1] ; Salmon, Carlos E. G. ^[2] ; Fukada, Sandra Y. ^[3] ; Nogueira-Barbosa, Marcello H. ^[1] ; Elias, Jr., Jorge ^[1] ; Freitas, Maria C. F. ^[1] ; Couri, Carlos E. B. ^[1] ; Oliveira, Maria C. ^[1] ; Simoes, Belinda P. ^[1] ; Rosen, Clifford J. ^[4] ; de Paula, Francisco J. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Philosophy Sci & Arts Ribeirao Preto, Dept Phys, Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Ribeirao Preto - Brazil

^[4] Maine Med Ctr Res Inst, Ctr Clin & Translat Res, Scarborough, ME - USA

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL DENSITOMETRY; v. 22, n. 3, p. 420-428, JUL-SEP 2019.
• Citações Web of Science: 2

Resumo

Anthropomorphic measures among type 1 diabetic patients are changing as the obesity epidemic continues. Excess fat mass may impact bone density and ultimately fracture risk. We studied the interaction between bone and adipose tissue in type 1 diabetes subjects submitted to two different clinical managements: (I) conventional insulin therapy or (II) autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST). The study comprised 3 groups matched by age, gender, height and weight: control (C = 24), type 1 diabetes (T1D = 23) and type 1 diabetes treated with AHST (T1D-AHST = 9). Bone mineral density (BMD) and trabecular bone score (TBS) were assessed by dual X-ray absorptiometry (DXA). H-1 Magnetic resonance spectroscopy was used to assess bone marrow adipose tissue (BMAT) in the L3 vertebra, and abdominal magnetic resonance imaging was used to assess intrahepatic lipids (IHL), visceral (VAT) and subcutaneous adipose tissue (SAT). Individuals conventionally treated for T1D were more likely to be overweight (C = 23.8 +/- 3.7; T1D = 25.3 +/- 3.4; T1D-AHST = 22.5 +/- 2.2 Kg/m(2); p > 0.05), but there was no excessive lipid accumulation in VAT or liver. Areal BMD of the three groups were similar at all sites; lumbar spine TBS (L3) was lower in type 1 diabetes (p < 0.05). Neither SAT nor VAT had any association with bone parameters. Bone marrow adipose tissue (BMAT) lipid profiles were similar among groups. BMAT saturated lipids were associated with cholesterol, whereas unsaturated lipids had an association with IGF1. Overweight and normal weight subjects with type 1 diabetes have normal areal bone density, but lower trabecular bone scores. Adipose distribution is normal and BMAT volume is similar to controls, irrespective of clinical treatment. (AU)

• Processo FAPESP: 15/09034-0 - Efeito da O-GlcNacilação sobre a osteoclastogênese e reabsorção óssea
• Beneficiário: Sandra Yasuyo Fukada Alves
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/14505-0 - Efeitos do balanço energético sobre a massa óssea e a adiposidade da medula óssea no diabetes melito do tipo 1
• Beneficiário: Adriana Lelis Carvalho
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 14/15864-3 - Relação da adiposidade visceral, hepática e óssea com a densidade mineral óssea e ocorrência de fratura no Diabetes melito tipo 1
• Beneficiário: Francisco José Albuquerque de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/09853-6 - Relação da Adiposidade Visceral, Hepática e Óssea com a Densidade Mineral Óssea e Ocorrência de Fratura no Diabetes Melito tipo 1.
• Beneficiário: Adriana Lelis Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado