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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Emerging Aspects of the Body Composition, Bone Marrow Adipose Tissue and Skeletal Phenotypes in Type 1 Diabetes Mellitus

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Author(s):
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Carvalho, Adriana L. [1] ; Massaro, Bianca [1] ; e Silva, Luciana T. P. [1] ; Salmon, Carlos E. G. [2] ; Fukada, Sandra Y. [3] ; Nogueira-Barbosa, Marcello H. [1] ; Elias, Jr., Jorge [1] ; Freitas, Maria C. F. [1] ; Couri, Carlos E. B. [1] ; Oliveira, Maria C. [1] ; Simoes, Belinda P. [1] ; Rosen, Clifford J. [4] ; de Paula, Francisco J. A. [1]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Philosophy Sci & Arts Ribeirao Preto, Dept Phys, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Ribeirao Preto - Brazil
[4] Maine Med Ctr Res Inst, Ctr Clin & Translat Res, Scarborough, ME - USA
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF CLINICAL DENSITOMETRY; v. 22, n. 3, p. 420-428, JUL-SEP 2019.
Web of Science Citations: 2
Abstract

Anthropomorphic measures among type 1 diabetic patients are changing as the obesity epidemic continues. Excess fat mass may impact bone density and ultimately fracture risk. We studied the interaction between bone and adipose tissue in type 1 diabetes subjects submitted to two different clinical managements: (I) conventional insulin therapy or (II) autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST). The study comprised 3 groups matched by age, gender, height and weight: control (C = 24), type 1 diabetes (T1D = 23) and type 1 diabetes treated with AHST (T1D-AHST = 9). Bone mineral density (BMD) and trabecular bone score (TBS) were assessed by dual X-ray absorptiometry (DXA). H-1 Magnetic resonance spectroscopy was used to assess bone marrow adipose tissue (BMAT) in the L3 vertebra, and abdominal magnetic resonance imaging was used to assess intrahepatic lipids (IHL), visceral (VAT) and subcutaneous adipose tissue (SAT). Individuals conventionally treated for T1D were more likely to be overweight (C = 23.8 +/- 3.7; T1D = 25.3 +/- 3.4; T1D-AHST = 22.5 +/- 2.2 Kg/m(2); p > 0.05), but there was no excessive lipid accumulation in VAT or liver. Areal BMD of the three groups were similar at all sites; lumbar spine TBS (L3) was lower in type 1 diabetes (p < 0.05). Neither SAT nor VAT had any association with bone parameters. Bone marrow adipose tissue (BMAT) lipid profiles were similar among groups. BMAT saturated lipids were associated with cholesterol, whereas unsaturated lipids had an association with IGF1. Overweight and normal weight subjects with type 1 diabetes have normal areal bone density, but lower trabecular bone scores. Adipose distribution is normal and BMAT volume is similar to controls, irrespective of clinical treatment. (AU)

FAPESP's process: 15/09034-0 - The role of O-glycosylation on the modulation of osteoclastogenesis and bone resorption
Grantee:Sandra Yasuyo Fukada Alves
Support Opportunities: Regular Research Grants
FAPESP's process: 14/14505-0 - Effect of energy balance on bone mass and marrow fat in type 1 diabetes mellitus
Grantee:Adriana Lelis Carvalho
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/15864-3 - Relationship between visceral, hepatic and bone adiposity with bone mineral density and fracture occurrence in type 1 Diabetes mellitus
Grantee:Francisco José Albuquerque de Paula
Support Opportunities: Regular Research Grants
FAPESP's process: 13/09853-6 - Relationship between visceral, hepatic and bone adiposity with bone mineral density and fracture occurrence in type 1 diabetes mellitus.
Grantee:Adriana Lelis Carvalho
Support Opportunities: Scholarships in Brazil - Doctorate