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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Does stroke laterality predict major depression and cognitive impairment after stroke? Two-year prospective evaluation in the EMMA study

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Autor(es):
Baccaro, Alessandra [1] ; Wang, Yuan-Pang [2, 3] ; Brunoni, Andre Russowsky [1, 2] ; Candido, Miriam [1] ; Conforto, Adriana Bastos [4] ; Leite, Claudia da Costa [5, 6, 7] ; Lotufo, Paulo A. [6, 1] ; Bensenor, Isabela M. [6, 1] ; Goulart, Alessandra C. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Hosp Univ, Ctr Clin & Epidemiol Res, Av Prof Lineu Presses 2565, Butanta Cidade Univ, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Hosp Clin, Med Sch, Inst Psychiat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Lab Med Invest Psychopharmacol & Clin Psychophysi, Med Sch, Sao Paulo - Brazil
[4] Univ Sao Paulo, Hosp Clin, Med Sch, Dept Neurol, Sao Paulo - Brazil
[5] Univ Sao Paulo, NAPNA, Sao Paulo - Brazil
[6] Univ Sao Paulo, Med Sch, Sao Paulo - Brazil
[7] Univ Sao Paulo, Inst Radiol & Oncol, Hosp Clin, Sao Paulo - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 94, AUG 30 2019.
Citações Web of Science: 1
Resumo

Depression and cognitive impairment are common conditions following stroke. We aimed to evaluate stroke laterality as predictor of post-stroke depression (PSD) and cognitive impairment (PCI) in a stroke cohort. Major depression (Patient Health Questionnaire-9, score >= 10) and cognitive impairment (Modified Telephone Interview for Cognitive Status, score < 14) were evaluated at 6 months and yearly up to 2 years. Survival analyses were performed by Kaplan-Meier curves and Cox logistic regression models, adjusted for potential confounders (cumulative hazard ratio, HR; 95% confidence interval, CI), for the likelihood of subsequent PSD or PCI progression at 6 months and 2 years, according to stroke laterality (right hemisphere-reference). Among 100 stroke patients, we found 19% had PSD and 38% had PCI 2 years after stroke. Most participants (53%) presented right-sided stroke. However, right-sided stroke was not associated with PSD or PCI. Overall, left-sided stroke was an independent and long-term predictor of PCI, but not of major depression. Left-sided stroke was associated with a high probability of PCI (42.6% and 53.2%, respectively at 6 months and 2 years, p-log-rank: 0.002). The HR of PCI due to left-sided stroke was 3.25 (95% CI, 1.30-8.12) at 6 months and remained almost the same at 2 years (HR, 3.22;95% CI, 1.43-7.28). The risk of having worse cognition status increased by > 3 times, 2 years after stroke. The results support the hypothesis that involvement of networks in the left, but not in the right hemisphere, contribute to long-term cognitive impairment. Lesion laterality did not influence the risk of PSD. (AU)

Processo FAPESP: 15/17321-0 - Valor preditivo de biomarcadores e neuroimagem cerebral na evolução da depressão e prejuízo cognitivo pós-acidente vascular cerebral a longo prazo no estudo emma
Beneficiário:Alessandra Carvalho Goulart
Linha de fomento: Auxílio à Pesquisa - Regular