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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Does stroke laterality predict major depression and cognitive impairment after stroke? Two-year prospective evaluation in the EMMA study

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Author(s):
Baccaro, Alessandra [1] ; Wang, Yuan-Pang [2, 3] ; Brunoni, Andre Russowsky [1, 2] ; Candido, Miriam [1] ; Conforto, Adriana Bastos [4] ; Leite, Claudia da Costa [5, 6, 7] ; Lotufo, Paulo A. [6, 1] ; Bensenor, Isabela M. [6, 1] ; Goulart, Alessandra C. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Hosp Univ, Ctr Clin & Epidemiol Res, Av Prof Lineu Presses 2565, Butanta Cidade Univ, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Hosp Clin, Med Sch, Inst Psychiat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Lab Med Invest Psychopharmacol & Clin Psychophysi, Med Sch, Sao Paulo - Brazil
[4] Univ Sao Paulo, Hosp Clin, Med Sch, Dept Neurol, Sao Paulo - Brazil
[5] Univ Sao Paulo, NAPNA, Sao Paulo - Brazil
[6] Univ Sao Paulo, Med Sch, Sao Paulo - Brazil
[7] Univ Sao Paulo, Inst Radiol & Oncol, Hosp Clin, Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Source: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 94, AUG 30 2019.
Web of Science Citations: 1
Abstract

Depression and cognitive impairment are common conditions following stroke. We aimed to evaluate stroke laterality as predictor of post-stroke depression (PSD) and cognitive impairment (PCI) in a stroke cohort. Major depression (Patient Health Questionnaire-9, score >= 10) and cognitive impairment (Modified Telephone Interview for Cognitive Status, score < 14) were evaluated at 6 months and yearly up to 2 years. Survival analyses were performed by Kaplan-Meier curves and Cox logistic regression models, adjusted for potential confounders (cumulative hazard ratio, HR; 95% confidence interval, CI), for the likelihood of subsequent PSD or PCI progression at 6 months and 2 years, according to stroke laterality (right hemisphere-reference). Among 100 stroke patients, we found 19% had PSD and 38% had PCI 2 years after stroke. Most participants (53%) presented right-sided stroke. However, right-sided stroke was not associated with PSD or PCI. Overall, left-sided stroke was an independent and long-term predictor of PCI, but not of major depression. Left-sided stroke was associated with a high probability of PCI (42.6% and 53.2%, respectively at 6 months and 2 years, p-log-rank: 0.002). The HR of PCI due to left-sided stroke was 3.25 (95% CI, 1.30-8.12) at 6 months and remained almost the same at 2 years (HR, 3.22;95% CI, 1.43-7.28). The risk of having worse cognition status increased by > 3 times, 2 years after stroke. The results support the hypothesis that involvement of networks in the left, but not in the right hemisphere, contribute to long-term cognitive impairment. Lesion laterality did not influence the risk of PSD. (AU)

FAPESP's process: 15/17321-0 - PREDICTIVE VALUE OF BIOMARKERS AND NEUROIMAGING IN LONG-TERM EVOLUTION OF POST-STROKE DEPRESSION AND COGNITIVE IMPAIRMENT IN EMMA STUDY
Grantee:Alessandra Carvalho Goulart
Support type: Regular Research Grants