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PROGNOSTIC FACTORS ASSOCIATED WITH MORTALITY AND SURVIVAL UP TO 12 YEARS OF FOLLOW-UP IN THE MORTALITY AND MORBIDITY STROKE STUDY (EMMA STUDY).

Grant number: 18/05512-3
Support type:Regular Research Grants
Duration: September 01, 2018 - November 30, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Alessandra Carvalho Goulart
Grantee:Alessandra Carvalho Goulart
Home Institution: Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Isabela Judith Martins Bensenor ; Paulo Andrade Lotufo

Abstract

Introduction: Stroke causes a high burden of disability and mortality, especially in developing countries, such as Brazil. Thus, this project aims to evaluate stroke epidemiology face on prognostic factors associated with long-term survival over 12 years of follow-up in the EMMA Study (Mortality and Morbidity Stroke Study). Methodology: In addition, to baseline characteristics of stroke, this epidemiological surveillance of stroke includes the recording of fatal events (all-cause mortality, cardiovascular disease (CVD) and stroke) and non-fatal events (disability, depression and cognitive impairment after stroke). It will be the focus of this project to assess the impact of risk factors for cerebrovascular disease: pre-event index (presence of multimorbidities, pharmacotherapy for cardiovascular prevention), post-event index (disability by Rankin-modified scale at 6 months post-stroke, depression and cognitive impairment post-stroke) in the survival of patients with stroke (hemorrhagic and ischemic) up to 12 years of follow-up in the EMMA study. Stroke rates and associated events will be calculated, as well as, case-fatality rates using Chi-square tests for categorical variables and test for continuous variables depending on the distribution whether normal or not (T-Student or Mann-Whitney). In addition, survival analyzes will be performed, including Kaplan-Meier curves and Cox logistic regression for risk ratio (RR) calculation with 95% confidence intervals (95% CI) for all-cause death, CVD and stroke according to potential predictors pre- and post-event index up to 12 years of follow-up. Expected results: To determine the main factors associated with the occurrence of the two major subtypes of stroke, to determine case-fatality rates and long-term mortality by survival analyzes according to main potential predictive risk factors (pre-event: presence of multimorbidities, pharmacotherapy for cardiovascular and post-event prevention: Rankin-modified disability at 6 months post-stroke, depression, and post-stroke cognitive impairment) at follow-up of up to 12 years. Through this long-term project, we intend to offer tools to better approach of patient with high risk for cerebrovascular disease. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOULART, ALESSANDRA C.; OLMOS, RODRIGO DIAZ; SANTOS, ITAMAR S.; TUNES, GISELA; ALENCAR, AIRLANE P.; THOMAS, NEIL; LIP, GREGORY Y. H.; LOTUFO, PAULO A.; BENSENOR, ISABELA M. The impact of atrial fibrillation and long-term oral anticoagulant use on all-cause and cardiovascular mortality: A 12-year evaluation of the prospective Brazilian Study of Stroke Mortality and Morbidity. International Journal of Stroke, v. 17, n. 1, p. 48-58, JAN 2022. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.