Xylitol bioproduction: state-of-the-art, industrial paradigm shift, and opportunities for integrated biorefineries

Autor(es)

Hernandez-Perez, Andres Felipe ^[1] ; de Arruda, Priscila Vaz ^[2] ; Sene, Luciane ^[3] ; da Silva, Silvio Silverio ^[1] ; Chandel, Anuj Kumar ^[1] ; de Almeida Felipe, Maria das Gracas ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, EEL, Dept Biotecnol, BR-12602810 Lorena, SP - Brazil

^[2] Univ Tecnol Fed Parana, Dept Bioproc Engn & Biotechnol COEBB TD, Toledo - Brazil

^[3] Univ Estadual Oeste Parana UNIOESTE, Ctr Exact & Technol Sci, Cascavel - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CRITICAL REVIEWS IN BIOTECHNOLOGY; v. 39, n. 7 JULY 2019.
• Citações Web of Science: 0

Resumo

Recent advances in biomass conversion technologies have shown a promising future toward fermentation during xylitol production. Xylitol is one of the top 12 renewable added-value chemicals that can be obtained from biomass according to US Department of Energy (USDOE). Currently, xylitol accounts for approximately US\$823.6 million of annual sales in the market, and this amount is expected to reach US\$1.37 billion by 2025. This high demand has been achieved owing to the chemical conversion of hemicellulosic hydrolysates from different lignocellulosic biomasses, which is a costly and non-ecofriendly process. Xylose-rich hemicellulosic hydrolysates are the major raw materials for xylitol production through either chemical or biotechnological routes. Economic production of a clean hemicellulosic hydrolysate is one of the major bottlenecks for xylitol production on the commercial scale. Advancements in biotechnology, such as the isolation of novel microorganisms, genetic manipulation of xylose metabolizing strains, and modifications in the fermentation process, can enhance the economic feasibility of xylitol production on the large scale. Furthermore, xylitol production in integrated biorefineries can be even more economic, given the readily available raw materials and the co-use of steam, electricity, and water, among others. Exploring new biotechnology techniques in integrated biorefineries would open new markets and opportunities for sustainable xylitol production to fulfill the market's growing demands for this sugar alcohol. This article is a review of the advancements reported in the whole biotechnological process for xylitol production, and involve pretreatment technologies, hemicellulosic hydrolysate preparation, xylose conversion into xylitol, and product recovery. Special attention is devoted to current metabolic engineering strategies to improve this bioprocess, as well as to the importance of xylitol production processes in biorefineries. (AU)

• Processo FAPESP: 16/22179-0 - Melhorias no bioprocesso de produção de xilitol no conceito de biorrefinaria para diversificação do portfólio de produtos do setor sucroalcooleiro
• Beneficiário: Maria das Graças de Almeida Felipe
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/10636-8 - Da fábrica celular à biorrefinaria integrada Biodiesel-Bioetanol: uma abordagem sistêmica aplicada a problemas complexos em micro e macroescalas
• Beneficiário: Roberto de Campos Giordano
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOEN - Temático
• Processo FAPESP: 16/05971-2 - Produção biotecnológica de xilitol a partir da mistura de bagaço e palha de cana-de-açúcar com aproveitamento do melaço: otimização das condições de cultivo e engenharia da via metabólica
• Beneficiário: Andrés Felipe Hernández Pérez
• Modalidade de apoio: Bolsas no Brasil - Doutorado