Scorpion envenomation and inflammation: Beyond neurotoxic effects

Autor(es)

Reis, Mouzarllem Barros ^{[1, 2]} ; Zoccal, Karina Furlani ^[3] ; Gardinassi, Luiz Gustavo ^[1] ; Faccioli, Lucia Helena ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Programa Posgrad Imunol Bas & Aplicada, Ribeirao Preto, SP - Brazil

^[3] Ctr Univ Barao Maud, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Toxicon; v. 167, p. 174-179, SEP 2019.
• Citações Web of Science: 0

Resumo

Scorpion envenomation results in a wide range of clinical manifestations that are mostly attributed to the activation of the autonomic nervous system by venom toxins. In fact, sympathetic and parasympathetic disturbances play important roles during poisoning. However, scorpion venom also induces a complex hyperin-flammatory state that occurs parallel to systemic inflammatory response syndrome and acute sepsis. After a scorpion sting, innate immune cells are exposed to the venom molecules, which bind to pattern recognition receptors and activate pro-inflammatory pathways that contribute toward the promotion of severe symptoms, such as pulmonary edema, and eventually lead to death. In this review, we highlight studies that pointed out inflammation as a major pathological facet of scorpion envenomation, so as to provide novel targets to improve therapeutics for scorpionism. (AU)

• Processo FAPESP: 17/02314-3 - Investigação sobre alterações cardíacas que ocorrem no envenenamento pela peçonha do escorpião Tityus serrulatus
• Beneficiário: Mouzarllem Barros dos Reis
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/07125-6 - Novos aspectos funcionais dos eicosanóides
• Beneficiário: Lúcia Helena Faccioli
• Modalidade de apoio: Auxílio à Pesquisa - Temático