Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals

Autor(es):Mostrar menos -

Opazo-Capurro, Andres ^{[1, 2]} ; San Martin, Ivan ^[1] ; Quezada-Aguiluz, Mario ^[1] ; Morales-Leon, Felipe ^{[1, 3]} ; Dominguez-Yevenes, Mariana ^[1] ; Lima, Celia A. ^[1] ; Esposito, Fernanda ^[4] ; Cerdeira, Louise ^[4] ; Bello-Toledo, Helia ^[1] ; Lincopan, Nilton ^{[5, 4]} ; Gonzalez-Rocha, Gerardo ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Concepcion, Fac Ciencias Biol, Dept Microbiol, LIAA, UdeC, Concepcion - Chile

^[2] Millennium Nucleus Collaborat Res Bacterial Resis, Santiago - Chile

^[3] Univ Concepcion, Fac Farm, Dept Farm, Concepcion - Chile

^[4] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INFECTION GENETICS AND EVOLUTION; v. 73, p. 93-97, SEP 2019.
• Citações Web of Science: 4

Resumo

We analyze the evolutionary dynamics of ninety carbapenem-resistant Acinetobacter baumannii (CRAB) isolates collected between 1990 and 2015 in Chile. CRAB were identified at first in an isolate collected in 2005, which harbored the ISAba1-bla(OAX-69) arrangement. Later, OXA-58- and OXA-23-producing A. baumannii strains emerged in 2007 and 2009, respectively. This phenomenon was associated with variations in the epidemiology of OXA-type carbapenemases, linked to nosocomial lineages belonging to ST109, ST162, ST15 (CC15) and ST318 (CC15). (AU)

• Processo FAPESP: 16/08593-9 - Pan-resistoma de Klebsiella pneumoniae e Escherichia coli produtoras de beta-lactamases (KPC-2, CTX-M-8, CTX-M-15) endêmicas no Brasil
• Beneficiário: Nilton Erbet Lincopan Huenuman
• Modalidade de apoio: Auxílio à Pesquisa - Regular