Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Zika Virus Infects Newborn Monocytes Without Triggering a Substantial Cytokine Response

Texto completo
Autor(es):
Yamada Yoshikawa, Fabio Seiti [1] ; Pietrobon, Anna Julia [2, 1] ; Calvielli Castelo Branco, Anna Claudia [2, 1] ; Pereira, Natalli Zanete [2, 1] ; da Silva Oliveira, Luanda Mara [1] ; Machado, Clarisse Martins [3] ; da Silva Duarte, Alberto Jose [1] ; Sato, Maria Notomi [2, 1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Inst Med Trop, Lab Invest Dermatol & Imunodeficiencias, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Med Trop, Lab Virol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Infectious Diseases; v. 220, n. 1, p. 32-40, JUL 1 2019.
Citações Web of Science: 1
Resumo

Zika virus (ZIKV) is a clinically important flavivirus that can cause neurological disturbances in newborns. Here, we investigated comparatively the outcome of in vitro infection of newborn monocytes by ZIKV. We observed that neonatal cells show defective production of interleukin 1 beta, interleukin 10, and monocyte chemoattractant protein 1 in response to ZIKV, although they were as efficient as adult cells in supporting viral infection. Although CLEC5A is a classical flavivirus immune receptor, it is not essential to the cytokine response, but it regulates the viral load only in adult cells. Greater expression of viral entry receptors may create a favorable environment for viral invasion in neonatal monocytes. We are the first to suggest a role for CLEC5A in human monocyte infectivity and to show that newborn monocytes are interesting targets in ZIKV pathogenesis, owing to their ability to carry the virus with only a partial triggering of the immune response, creating a potentially favorable environment for virus-related pathologies in young individuals. (AU)

Processo FAPESP: 16/09764-1 - Papel dos receptores de lectina tipo C na infecção de monócitos de recém-natos por Zika vírus
Beneficiário:Fábio Seiti Yamada Yoshikawa
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/16840-6 - Análise de fatores antivirais e exossomas em trofoblastos e monócitos de recém-natos na infecção in vitro por Zika vírus
Beneficiário:Maria Notomi Sato
Linha de fomento: Auxílio à Pesquisa - Regular