A sensitive multiresidue method for the determination of pesticides in marijuana by liquid chromatography-tandem mass spectrometry

Autor(es)

Daniel, Daniela ^{[1, 2]} ; Lopes, Fernando Silva ^[1] ; do Lago, Claudimir Lucio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Av Prof Lineu Prestes 748, BR-05508000 Butanta, SP - Brazil

^[2] Agilent Technol Brasil Ltda, Av Marcos Penteado Ulhoa Rodrigues 939, 6 Andar, BR-06460040 Torre Jacaranda, Barueri - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Chromatography A; v. 1603, p. 231-239, OCT 2019.
• Citações Web of Science: 1

Resumo

A multiresidue method based on QuEChERS extraction followed liquid chromatography coupled with tandem mass spectrometry was developed and validated for the determination of 42 pesticides in marijuana. Less than 6 min is required for detection of all species. By using original QuEChERS, the sample preparation is also fast and simple. In the range from 1.0 to 50 mu g kg(-1), the coefficients of determination (r(2)) were greater than 0.980, and relative standard deviations for replicate injections were lower than 4.6%. The limit of detection (LOD) and limit of quantification (LOQ) were lower than 0.32 mu g kg(-1) and 1.07 mu g kg(-1), respectively. Precision and accuracy were verified through recovery of spiked samples at three distinct levels of concentration (1.0, 5.0, and 50.0 mu g kg(-1)) in five replicates. Recovery values ranged from 82 to 119% with RSD lower than 6%. The method was applied to the detection of pesticide residues in six marijuana samples seized by the Police of Rio de Janeiro, Brazil, where imidacloprid, metazachlor, buprofezin, and metalaxyl were found in four of them. (C) 2019 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 17/13137-5 - Formação e propriedades de hemiésteres do ácido carbônico em meio aquoso
• Beneficiário: Claudimir Lucio Do Lago
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/06642-1 - Formação e propriedades de adutos de hidróxi-compostos orgânicos com carbonato em meio aquoso e condições biológicas
• Beneficiário: Claudimir Lucio Do Lago
• Modalidade de apoio: Auxílio à Pesquisa - Regular