A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells

Autor(es):Mostrar menos -

Silva Rischiteli, Alessandra B. ^[1] ; Neto, Nelson I. P. ^[1] ; Gascho, Karina ^[1] ; Carnier, Marcela ^[1] ; de Miranda, Danielle A. ^[1] ; Silva, Fernanda P. ^[1] ; Boldarine, Valter T. ^[1] ; Seelaender, Marilia ^[2] ; Ribeiro, Eliane B. ^[1] ; Oyama, Lila M. ^[1] ; Oller do Nascimento, Claudia M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 14, n. 6 JUN 18 2019.
• Citações Web of Science: 0

Resumo

Objective The aim of this study was to evaluate the effect of adding xanthan gum to the diet of rats on the production of cytokines and pro-inflammatory factors and on tumor development in rats inoculated with Walker 256 tumor cells. Methods Fifty-six rats were divided into 4 groups: control diet (C), control diet with tumor (TC), xanthan gum diet (XG), xanthan gum diet with tumor (TXG). Results The ingestion of xanthan gum promotes changes in cytokine content: increasing IL-6 TNF-alpha and IL-10 in retroperitoneal adipose tissue compared to the control group; and increasing TNF-alpha in the mesenteric adipose tissue compared to the C and TXG groups. On the contrary, the addition of xanthan gum to the diet did not affect the development of Walker 256 tumors in rats. Conclusion The continuous use of xanthan gum triggered a pro-inflammatory response, promoting an increase in pro-inflammatory cytokines in the adipose tissue, but it did not have an effect on the tumor development in the animals inoculated with Walker 256 tumor cells. (AU)

• Processo FAPESP: 15/18249-0 - Efeito da suplementação alimentar com chia ou goma xantana no processo inflamatório associado ao câncer em ratos Wistar inoculados com tumor de Walker 256 e em células tumorais.
• Beneficiário: Claudia Maria da Penha Oller do Nascimento
• Modalidade de apoio: Auxílio à Pesquisa - Regular