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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells

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Author(s):
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Silva Rischiteli, Alessandra B. [1] ; Neto, Nelson I. P. [1] ; Gascho, Karina [1] ; Carnier, Marcela [1] ; de Miranda, Danielle A. [1] ; Silva, Fernanda P. [1] ; Boldarine, Valter T. [1] ; Seelaender, Marilia [2] ; Ribeiro, Eliane B. [1] ; Oyama, Lila M. [1] ; Oller do Nascimento, Claudia M. [1]
Total Authors: 11
Affiliation:
[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 14, n. 6 JUN 18 2019.
Web of Science Citations: 0
Abstract

Objective The aim of this study was to evaluate the effect of adding xanthan gum to the diet of rats on the production of cytokines and pro-inflammatory factors and on tumor development in rats inoculated with Walker 256 tumor cells. Methods Fifty-six rats were divided into 4 groups: control diet (C), control diet with tumor (TC), xanthan gum diet (XG), xanthan gum diet with tumor (TXG). Results The ingestion of xanthan gum promotes changes in cytokine content: increasing IL-6 TNF-alpha and IL-10 in retroperitoneal adipose tissue compared to the control group; and increasing TNF-alpha in the mesenteric adipose tissue compared to the C and TXG groups. On the contrary, the addition of xanthan gum to the diet did not affect the development of Walker 256 tumors in rats. Conclusion The continuous use of xanthan gum triggered a pro-inflammatory response, promoting an increase in pro-inflammatory cytokines in the adipose tissue, but it did not have an effect on the tumor development in the animals inoculated with Walker 256 tumor cells. (AU)

FAPESP's process: 15/18249-0 - Effect of chia or xanthan gum supplementation on inflammatory process associated with cancer in Wistar rats inoculated with Walker 256 tumour and in tumor cells.
Grantee:Claudia Maria da Penha Oller do Nascimento
Support Opportunities: Regular Research Grants