Potential Triazole-based Molecules for the Treatment of Neglected Diseases

Autor(es)

Mantoani, Susimaire Pedersoli ^[1] ; de Andrade, Peterson ^[1] ; Cantuaria Chierrito, Talita Perez ^[1] ; Figueredo, Andreza Silva ^[1] ; Carvalho, Ivone ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Current Medicinal Chemistry; v. 26, n. 23, p. 4403-4434, 2019.
• Citações Web of Science: 2

Resumo

Neglected Diseases (NDs) affect million of people, especially the poorest population around the world. Several efforts to an effective treatment have proved insufficient at the moment. In this context, triazole derivatives have shown great relevance in medicinal chemistry due to a wide range of biological activities. This review aims to de- scribe some of the most relevant and recent research focused on 1,2,3- and 1,2,4-triazole-based molecules targeting four expressive NDs: Chagas disease, Malaria, Tuberculosis and Leishmaniasis. (AU)

• Processo FAPESP: 08/00373-3 - Síntese e avaliação de potenciais inibidores de trans-sialidase de Trypanosoma cruzi
• Beneficiário: Ivone Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Regular