Potential Triazole-based Molecules for the Treatment of Neglected Diseases

Mantoani, Susimaire Pedersoli; de Andrade, Peterson; Cantuaria Chierrito, Talita Perez; Figueredo, Andreza Silva; Carvalho, Ivone

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Potential Triazole-based Molecules for the Treatment of Neglected Diseases

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Author(s):	Mantoani, Susimaire Pedersoli ^[1] ; de Andrade, Peterson ^[1] ; Cantuaria Chierrito, Talita Perez ^[1] ; Figueredo, Andreza Silva ^[1] ; Carvalho, Ivone ^[1] Total Authors: 5
Affiliation:	^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil Total Affiliations: 1
Document type:	Review article
Source:	Current Medicinal Chemistry; v. 26, n. 23, p. 4403-4434, 2019.
Web of Science Citations:	2
Abstract
Neglected Diseases (NDs) affect million of people, especially the poorest population around the world. Several efforts to an effective treatment have proved insufficient at the moment. In this context, triazole derivatives have shown great relevance in medicinal chemistry due to a wide range of biological activities. This review aims to de- scribe some of the most relevant and recent research focused on 1,2,3- and 1,2,4-triazole-based molecules targeting four expressive NDs: Chagas disease, Malaria, Tuberculosis and Leishmaniasis. (AU)

FAPESP's process:	08/00373-3 - Synthesis and evaluation of potential inhibitors of trypanosoma cruzi trans-sialidase
Grantee:	Ivone Carvalho
Support Opportunities:	Regular Research Grants

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