Ventricular arrhythmias in the Chagas disease are not random phenomena: Long-term monitoring in Chagas arrhythmias

Autor(es)

Ferreira Silva, Nancy Christiane ^[1] ; Reis, Maria do Carmo M. ^[1] ; Povoa, Rui M. dos S. ^[1] ; de Paola, Angelo A. V. ^[1] ; Filho, Braulio Luna ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Cardiol, Rua Napoleao Barros 715, BR-04024002 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY; v. 30, n. 11, p. 2370-2376, NOV 2019.
• Citações Web of Science: 0

Resumo

Background Variability of ventricular arrhythmias among days in patients with Chagas disease is not detected by 24 hours of Holter monitoring. Objective To analyze whether ventricular arrhythmias are a random phenomenon or have a reproducible behavior in patients with Chagas cardiomyopathy. Method Holter monitoring was recorded in 16 subjects with a mean age of 52 +/- 8 years. They were clinically stable and had ventricular couplets, isolated premature ventricular contractions (PVCs), and nonsustained ventricular tachycardia (NSVT). The recordings occurred for 7 days. Hurst exponent (HE) evaluated randomness and predictability index (PI) and repeated analysis of variance (ANOVA) assessed reproducibility. Results The HE was significantly greater than 0.5 in all 16 patients, which confirms the nonrandomness of arrhythmias in this Chagas sample. The PI for ventricular couplets and isolated PVCs was, on average, 38% and 54%, respectively. ANOVA with repeated measurement showed significant differences in the daily frequency of ventricular couplets (n = 15, P <= .05), isolated PVC (n = 12, P <= .05), and NSVT (n = 7, P <= .05). Conclusion Ventricular arrhythmias in Chagas cardiomyopathy are not random. Dissimilarities in arrhythmias frequency make unlikely that 24 hours of Holter recording can capture this variability. (AU)

• Processo FAPESP: 98/08172-3 - Análise estocástica da dinâmica temporal das arritmias cardíacas, por meio da gravação intermitente do eletrocardiograma, por períodos de tempo muito longos
• Beneficiário: Ricardo Geretto Kortas
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE