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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Inflammation in Renal Diseases: New and Old Players

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Autor(es):
Andrade-Oliveira, Vinicius [1, 2] ; Foresto-Neto, Orestes [3] ; Mizuno Watanabe, Ingrid Kazue [1, 4] ; Zatz, Roberto [3] ; Saraiva Camara, Niels Olsen [1, 4, 3]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, Sao Paulo - Brazil
[2] Fed Univ ABC, Ctr Nat & Human Sci, Bernardos Lab, Santo Andre, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Nephrol Div, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN PHARMACOLOGY; v. 10, OCT 8 2019.
Citações Web of Science: 1
Resumo

Inflammation, a process intimately linked to renal disease, can be defined as a complex network of interactions between renal parenchymal cells and resident immune cells, such as macrophages and dendritic cells, coupled with recruitment of circulating monocytes, lymphocytes, and neutrophils. Once stimulated, these cells activate specialized structures such as Toll-like receptor and Nod-like receptor (NLR). By detecting danger-associated molecules, these receptors can set in motion major innate immunity pathways such as nuclear factor kappa B (NF-kappa B) and NLRP3 inflammasome, causing metabolic reprogramming and phenotype changes of immune and parenchymal cells and triggering the secretion of a number of inflammatory mediators that can cause irreversible tissue damage and functional loss. Growing evidence suggests that this response can be deeply impacted by the crosstalk between the kidneys and other organs, such as the gut. Changes in the composition and/or metabolite production of the gut microbiota can influence inflammation, oxidative stress, and fibrosis, thus offering opportunities to positively manipulate the composition and/or functionality of gut microbiota and, consequentially, ameliorate deleterious consequences of renal diseases. In this review, we summarize the most recent evidence that renal inflammation can be ameliorated by interfering with the gut microbiota through the administration of probiotics, prebiotics, and postbiotics. In addition to these innovative approaches, we address the recent discovery of new targets for drugs long in use in clinical practice. Angiotensin II receptor antagonists, NF-kappa B inhibitors, thiazide diuretics, and antimetabolic drugs can reduce renal macrophage infiltration and slow down the progression of renal disease by mechanisms independent of those usually attributed to these compounds. Allopurinol, an inhibitor of uric acid production, has been shown to decrease renal inflammation by limiting activation of the NLRP3 inflammasome. So far, these protective effects have been shown in experimental studies only. Clinical studies will establish whether these novel strategies can be incorporated into the arsenal of treatments intended to prevent the progression of human disease. (AU)

Processo FAPESP: 12/10926-5 - Patogênese e terapêutica da doença renal crônica: papel da imunidade inata na lesão de glomérulos, túbulos e interstício
Beneficiário:Roberto Zatz
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 18/17513-4 - Inflamassoma NLRP3 e o metabolismo glicolítico de células epiteliais tubulares no desenvolvimento da fibrose renal
Beneficiário:Ingrid Kazue Mizuno Watanabe
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 17/05264-7 - Metabolismo celular, microbiota e sistema imune: novos paradigmas na fisiopatologia das doenças renais
Beneficiário:Niels Olsen Saraiva Câmara
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 19/02893-9 - O fator induzido por hipóxia 1 alfa (HIF-1 alfa) e o metabolismo de células epiteliais tubulares e podócitos no desenvolvimento e na progressão da doença renal experimental
Beneficiário:Orestes Foresto Neto
Linha de fomento: Bolsas no Brasil - Pós-Doutorado